Bulată-Pop Irina, Cozma Angela, Briciu Violeta Tincuţa, Lupşe Mihaela Sorina, Junie Lia-Monica
Department of Microbiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
The Clinical Hospital of Infectious Diseases, Cluj-Napoca, Romania.
Med Pharm Rep. 2025 Jan;98(1):54-59. doi: 10.15386/mpr-2850. Epub 2025 Jan 31.
The infection with SARS-CoV-2 in children usually manifests as a mild respiratory tract infection. The aim of this study was to evaluate the severity, outcome and vaccination status in children hospitalized for COVID-19 in a single center during two pandemic waves determined by different SARS-CoV-2 variants of concern (VOCs).
A retrospective study on 656 consecutive pediatric patients was performed from September 1, 2021, to April 30, 2023. The study interval was divided into waves, according to official data on the circulation of Delta and Omicron VOCs. Data collected included sex, age, comorbidities, date of diagnosis, duration of hospitalization, vaccination status, clinical outcome.
The Delta group consisted of 234 children with a mean age of approximately 9 years, while the Omicron group included 422 children with a mean age of around 2.5 years. Most cases were mild, although in the Omicron wave the hospitalization rate was higher and 41.7% of the cases were medium in severity. The presence of comorbidities was not linked to an increase in severity. Vaccination rates were low in both groups, with a mean of 4% for the total of eligible patients.
This pioneering study highlights the nature of COVID-19 in children, focusing on both clinical aspects and public health issues.
儿童感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）通常表现为轻度呼吸道感染。本研究的目的是评估在由不同的关注的SARS-CoV-2变异株（VOCs）所决定的两个疫情波期间，在单一中心因新冠病毒病（COVID-19）住院的儿童的病情严重程度、转归及疫苗接种状况。
对2021年9月1日至2023年4月30日期间连续收治的656例儿科患者进行回顾性研究。根据关于德尔塔和奥密克戎VOCs传播的官方数据，将研究间隔划分为不同疫情波。收集的数据包括性别、年龄、合并症、诊断日期、住院时长、疫苗接种状况、临床转归。
德尔塔组有234名儿童，平均年龄约为9岁，而奥密克戎组包括422名儿童，平均年龄约为2.5岁。大多数病例为轻症，尽管在奥密克戎疫情波期间住院率更高，且41.7%的病例病情为中度。合并症的存在与病情严重程度增加无关。两组的疫苗接种率均较低， eligible患者总数的平均接种率为4%。
这项开创性研究突出了儿童COVID-19的特点，兼顾了临床方面和公共卫生问题。
