Sharma Lakshika, Sinha Dakshita Joy, Paul Rohit, Singh Shipra, Deb Anisha, Pandey Jayati
Department of Conservative Dentistry and Endodontics, Inderprastha Dental College and Hospital, Ghaziabad, Uttar Pradesh, India.
J Conserv Dent Endod. 2025 Jul;28(7):663-668. doi: 10.4103/JCDE.JCDE_259_25. Epub 2025 Jul 2.
The increasing prevalence of antibiotic resistance and concerns regarding adverse drug reactions have prompted interest in natural alternatives for antimicrobial treatments, particularly in endodontics.
This study aimed to evaluate the antimicrobial effectiveness of mangosteen, chitosan, and their combination as intracanal medicaments against .
A double-blind, randomized clinical trial was conducted involving 40 patients with single-rooted nonvital teeth ( = 10 per group). Patients were assigned to four groups: Group 1 - Mangosteen, Group 2 - Chitosan, Group 3 - Mangosteen with Chitosan, and Group 4 - Calcium Hydroxide (Ca(OH), control). Samples were collected before chemo-mechanical preparation (S1) and after 7 days of medicament application (S2).
Following standard intracanal procedures, medicaments were applied, and bacterial samples were collected at baseline and after treatment. Colony-forming units (CFU) were assessed to measure the bacterial load.
Data were analyzed using the one-way analysis of variance ( < 0.05) followed by post hoc Tukey test to compare CFU reductions among groups.
All groups showed significant CFU reduction. The Mangosteen with Chitosan group demonstrated the highest reduction (84.57%), followed by Chitosan (79.99%), Mangosteen (77.06%), and Ca(OH). No adverse effects were reported.
The combination of mangosteen and chitosan showed the most effective antimicrobial activity, suggesting its potential as a natural and effective intracanal medicament.
抗生素耐药性的日益普遍以及对药物不良反应的担忧促使人们对抗菌治疗的天然替代品产生兴趣，尤其是在牙髓病学领域。
本研究旨在评估山竹、壳聚糖及其组合作为根管内药物对……的抗菌效果。
进行了一项双盲、随机临床试验，纳入40名单根无活力牙患者（每组 = 10人）。患者被分为四组：第1组 - 山竹组，第2组 - 壳聚糖组，第3组 - 山竹与壳聚糖组合组，第4组 - 氢氧化钙（Ca(OH)，对照组）。在化学机械预备前（S1）和药物应用7天后（S2）采集样本。
按照标准的根管内操作程序应用药物，并在基线和治疗后采集细菌样本。评估菌落形成单位（CFU）以测量细菌载量。
采用单因素方差分析（< 0.05），随后进行事后Tukey检验以比较各组CFU减少情况。
所有组的CFU均显著减少。山竹与壳聚糖组合组的减少率最高（84.57%），其次是壳聚糖组（79.99%）、山竹组（77.06%）和氢氧化钙组。未报告不良反应。
山竹和壳聚糖的组合显示出最有效的抗菌活性，表明其作为天然有效根管内药物的潜力。
