Yan Ren, Zhang Xueliang, Wang Hai, Wang Tikang, Ren Guozhang, Sun Qizeng, Liang Fei, Zhu Yangzhi, Huang Wei, Yu Hai-Dong
Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an, 710072, P. R. China.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Adv Mater. 2025 Mar;37(12):e2418074. doi: 10.1002/adma.202418074. Epub 2025 Feb 17.
Electrotherapy has shown considerable potential in treating chronic wounds, but conventional approaches relying on bulky external power supplies and mechanical force are limited in their clinical utility. This study introduces an autonomous, moisture-driven flexible electrogenerative dressing (AMFED) that overcomes these limitations. The AMFED integrates a moist-electric generator (MEG), an antibacterial hydrogel dressing, and concentric molybdenum (Mo) electrodes to provide a self-sustaining electrical supply and potent antibacterial activity against Staphylococcus aureus and Escherichia coli. The MEG harnesses chemical energy from moisture to produce a stable direct current of 0.61 V without external input, delivering this therapeutic electrical stimulation to the wound site through the Mo electrodes. The AMFED facilitates macrophage polarization toward reparative M2 phenotype and regulates inflammatory cytokines. Moreover, in vivo studies suggest that the AMFED group significantly enhances chronic wound healing, with an approximate 41% acceleration compared to the control group. Using a diabetic mouse wound model, the AMFED demonstrates its effectiveness in promoting nerve regulation, epithelial migration, and vasculogenesis. These findings present a novel and efficient platform for accelerating chronic wound healing.
电疗法在治疗慢性伤口方面已显示出相当大的潜力，但依赖笨重外部电源和机械力的传统方法在临床应用中受到限制。本研究介绍了一种自主的、受水分驱动的柔性发电敷料（AMFED），它克服了这些限制。AMFED集成了一个湿电发生器（MEG）、一种抗菌水凝胶敷料和同心钼（Mo）电极，以提供自持电源，并对金黄色葡萄球菌和大肠杆菌具有强大的抗菌活性。MEG利用水分中的化学能在无外部输入的情况下产生0.61 V的稳定直流电，并通过Mo电极将这种治疗性电刺激传递到伤口部位。AMFED促进巨噬细胞向修复性M2表型极化，并调节炎性细胞因子。此外，体内研究表明，与对照组相比，AMFED组显著加速慢性伤口愈合，加速幅度约为41%。在糖尿病小鼠伤口模型中，AMFED证明了其在促进神经调节、上皮迁移和血管生成方面的有效性。这些发现为加速慢性伤口愈合提供了一个新颖且高效的平台。
