Li Min, Ding Lu, Cao Liyan, Zhang Zepeng, Li Xueyan, Li Zirui, Xia Qinjing, Yin Kai, Song Siyu, Wang Zihan, Du Haijian, Zhao Daqing, Li Xiangyan, Wang Zeyu
Northeast Asia Research Institute of Traditional Chinese Medicine, Key Laboratory of Active Substances and Biological Mechanisms of Ginseng Efcacy, Ministry of Education, Jilin Provincial Key Laboratory of Bio-Macromolecules of Chinese Medicine, Changchun University of Chinese Medicine, Jilin, China.
Research Center of Traditional Chinese Medicine, The Affiliated Hospital to Changchun University of Chinese Medicine, Jilin, China.
Front Pharmacol. 2025 Feb 3;16:1534634. doi: 10.3389/fphar.2025.1534634. eCollection 2025.
Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or a functional defect in the insulin itself. Clinically, diabetes is primarily classified into type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, the global incidence of T2DM has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway is crucial in regulating cellular energy metabolism, marking it as a significant therapeutic target for diabetes and related complications. Natural products, characterized by their diverse origins, multifaceted bioactivities, and relative safety, hold considerable promise in modulating the AMPK pathway. This review article explores the advances in research on natural products that target the AMPK signaling pathway, aiming to inform the development of innovative antidiabetic therapies.
糖尿病（DM）是最常见的慢性代谢性疾病之一，主要特征是血糖水平持续升高。这种情况通常源于胰岛素分泌不足或胰岛素本身的功能缺陷。临床上，糖尿病主要分为1型糖尿病（T1DM）和2型糖尿病（T2DM），其中T2DM占所有确诊病例的近90%。值得注意的是，近几十年来，全球T2DM的发病率急剧上升。腺苷酸活化蛋白激酶（AMPK）信号通路在调节细胞能量代谢中起着关键作用，这使其成为治疗糖尿病及相关并发症的重要靶点。天然产物具有来源多样、生物活性多方面且相对安全的特点，在调节AMPK通路方面具有很大的潜力。这篇综述文章探讨了针对AMPK信号通路的天然产物的研究进展，旨在为创新抗糖尿病疗法的开发提供参考。
