Fathabadi Ayoub, Khorashadizadeh Fatemeh, Darrudi Reza, Maroosi Mohammad
Department of Health Information Technology, Faculty of Health and Paramedicine, Neyshabur University of Medical Sciences, Neyshabur, Iran.
Department of Epidemiology and Biostatistics, Neyshabur University of Medical Sciences, Neyshabur, Iran.
PLoS One. 2025 Feb 18;20(2):e0318503. doi: 10.1371/journal.pone.0318503. eCollection 2025.
Human brucellosis is a global endemic disease and a significant public health concern. This cross-sectional study aims to explore the characteristics of human brucellosis, as well as its spatial and temporal clustering.
This cross-sectional study analyzed the population infected with human brucellosis in Neyshabur, Iran from 2015 to 2022. Data were obtained from the Neyshabur health center. Spatial analysis was conducted using Anselin Local Moran's I and Global Moran's I with ArcGIS 10.8.2. Descriptive statistical analyses were performed using SPSS 26.
During the study period, a total of 4568 brucellosis patients were reported. The incidence of disease was higher in men with 55.37%. The majority of patients belonged to the 30 to 39-year-old age group. Temporal clustering analysis revealed a peak incidence between March and June. The highest incidence rates were observed in spring and summer, with 34.76% and 33.84% of cases, respectively. Spatial clustering analysis indicated a higher prevalence in the southern and southeast districts of Neyshabur. The results of Global Moran's I analysis indicated that the distribution of brucellosis was not clustered in Neyshabur (P-value > 0.05).
The findings of this study highlight the importance of educational programs for mothers and animal vaccination strategies, particularly in the months leading up to the peak brucellosis season in high-incidence areas. Further research is needed to assess the coverage of livestock vaccination and its impact on human brucellosis rates.
人类布鲁氏菌病是一种全球性地方病，也是一个重大的公共卫生问题。这项横断面研究旨在探讨人类布鲁氏菌病的特征及其时空聚集性。
这项横断面研究分析了2015年至2022年伊朗内沙布尔感染人类布鲁氏菌病的人群。数据来自内沙布尔健康中心。使用ArcGIS 10.8.2进行安塞林局部莫兰指数I和全局莫兰指数I的空间分析。使用SPSS 26进行描述性统计分析。
在研究期间，共报告了4568例布鲁氏菌病患者。男性的发病率较高，为55.37%。大多数患者属于30至39岁年龄组。时间聚集分析显示3月至6月发病率达到峰值。春季和夏季的发病率最高，分别为34.76%和33.84%。空间聚集分析表明，内沙布尔南部和东南部地区的患病率较高。全局莫兰指数I分析结果表明，布鲁氏菌病在内沙布尔的分布没有聚集性（P值>0.05）。
本研究结果强调了针对母亲的教育计划和动物疫苗接种策略的重要性，特别是在高发病地区布鲁氏菌病发病高峰期前的几个月。需要进一步研究来评估牲畜疫苗接种的覆盖率及其对人类布鲁氏菌病发病率的影响。
