Mwasi L M, Raviola G
Graefes Arch Clin Exp Ophthalmol. 1985;223(1):9-15. doi: 10.1007/BF02150567.
Extrinsic eye muscles are very different from other skeletal muscles with regard to the morphology of their fibers and response to drugs. In addition, they are provided with an unusually rich blood supply. Since it had been previously reported that the capillaries of extraocular muscles are, at least in part, of the fenestrated type, a feature unusual for skeletal muscles, we have analyzed the morphology of these vessels in macaque monkeys and tested their permeability properties with horseradish peroxidase (HRP). Our study of the blood capillaries in the superior rectus muscle and levator palpebrae superioris in Macaca mulatta and M. fascicularis has demonstrated that these vessels are morphologically similar to the capillaries of other skeletal muscles. Furthermore, when HRP is introduced intravenam, it is transported out of the vessels by a vesicular transcellular mechanism. When HRP is injected in the interstitial spaces of the muscles, it is returned to the lumen by an identical vesicular transcellular transport. Thus, a bidirectional movement of macromolecules can take place across the walls of these vessels, and such a movement is not different from that previously reported for other skeletal muscles.
眼外肌在纤维形态和对药物的反应方面与其他骨骼肌有很大不同。此外，它们的血液供应异常丰富。由于此前有报道称眼外肌的毛细血管至少部分是有孔型的，这是骨骼肌不常见的特征，我们分析了猕猴中这些血管的形态，并用辣根过氧化物酶（HRP）测试了它们的通透性。我们对猕猴上直肌和上睑提肌中毛细血管的研究表明，这些血管在形态上与其他骨骼肌的毛细血管相似。此外，当HRP静脉内注入时，它通过囊泡跨细胞机制从血管中转运出来。当HRP注射到肌肉的间隙中时，它通过相同的囊泡跨细胞转运回到管腔。因此，大分子可以在这些血管壁上进行双向移动，并且这种移动与先前报道的其他骨骼肌的移动没有不同。
