Kaushik Atul, Patel Surendra, Goswami Sourabh, Garg Pawan, Goel Akhil Dhanesh, Meena Danishwar, Katti Madhusudan, Das Anupam, Choudhary Rahul, Deora Surender, Sharma Alok Kumar
Department of Cardiology, All India Institute of Medical Sciences, Jodhpur, India.
Department of Cardiothoracic and Vascular Surgery, All India Institute of Medical Sciences, Jodhpur, India.
Indian J Thorac Cardiovasc Surg. 2025 Mar;41(3):264-271. doi: 10.1007/s12055-024-01824-4. Epub 2024 Sep 26.
BACKGROUND/OBJECTIVE: Atherosclerosis is a systemic multifocal disease which most commonly involves branching points of the large and medium-sized arteries. The carotid intima-media thickness (c-IMT) is an established marker for increased cardiovascular risk and cerebrovascular disease. In this study, we aimed to establish the role of femoral intima-media thickness (FIMT) in predicting cardiovascular risk in angiographically confirmed patients of coronary artery disease (CAD) when compared with apparently healthy patients (having normal coronary angiogram).
A total of 114 consecutive patients presented at our institute with symptoms of CAD who underwent coronary angiogram were included in the study. After the coronary angiogram, patients were divided into three groups, group A having normal coronary angiogram, group B having CAD with a synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score of more than 22, and group C having CAD with a SYNTAX score of 22 or less. The Doppler ultrasound of the bilateral femoral artery in each patient was done 1 day before a coronary angiogram and FIMT was recorded.
There was a significant difference (-value - < 0.001) found in the mean FIMT in patients with normal coronaries (mean FIMT - 0.49 ± 0.05) and patients having CAD (mean FIMT - 0.73 ± 0.17). The area under the receiver operating characteristic (ROC) curve of mean FIMT in predicting abnormal coronaries was 0.903 (95%CI 0.847-0.958, < 0.001).
The FIMT has a strong correlation with coronary artery disease. With the help of this non-invasive tool, we can diagnose subclinical atherosclerosis and it may contribute to the prevention of CAD and its severe manifestations.
背景/目的：动脉粥样硬化是一种全身性多灶性疾病，最常累及大中型动脉的分支点。颈动脉内膜中层厚度（c-IMT）是心血管风险增加和脑血管疾病的既定标志物。在本研究中，我们旨在确定与明显健康的患者（冠状动脉造影正常）相比，股动脉内膜中层厚度（FIMT）在预测经血管造影证实的冠心病（CAD）患者心血管风险中的作用。
本研究纳入了114例连续到我院就诊、有CAD症状并接受冠状动脉造影的患者。冠状动脉造影后，患者被分为三组，A组冠状动脉造影正常，B组为CAD且经皮冠状动脉介入联合紫杉醇与心脏手术（SYNTAX）评分大于22，C组为CAD且SYNTAX评分为22或更低。在冠状动脉造影前1天对每位患者的双侧股动脉进行多普勒超声检查并记录FIMT。
冠状动脉正常的患者（平均FIMT - 0.49±0.05）和患有CAD的患者（平均FIMT - 0.73±0.17）的平均FIMT存在显著差异（-值 - < 0.001）。平均FIMT预测异常冠状动脉的受试者操作特征（ROC）曲线下面积为0.903（95%CI 0.847 - 0.958，< 0.001）。
FIMT与冠状动脉疾病密切相关。借助这种非侵入性工具，我们可以诊断亚临床动脉粥样硬化，它可能有助于预防CAD及其严重表现。
