Yang Zhaojun, Luo Yehao, He Jiali, Yuan Yahui, Liu Qiaoyun, Guo Jingyi, Lin Yuping, Sun Lu, Fan Guanjie
The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, China; Department of Endocrinology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Department of Endocrinology, Guangdong Provincial Hospital of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou 510120, China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China.
Department of Endocrinology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China; Department of Endocrinology, Guangdong Provincial Hospital of Chinese Medicine, 111 Dade Road, Yuexiu District, Guangzhou 510120, China; Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou 510120, China.
J Psychosom Res. 2025 Apr;191:112070. doi: 10.1016/j.jpsychores.2025.112070. Epub 2025 Feb 19.
Chronic sleep deprivation is widespread and associated with detrimental health outcomes, including inflammation. A common strategy to address weekday sleep deficits is weekend catch-up sleep (WCS). However, the relevance of the WCS on systemic inflammation, as quantified by the systemic immune-inflammation index (SII), remains inadequately understood.
This cross-sectional analysis examined data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 cohort. To explore the relationship between the WCS and the SII, we employed univariate analysis, weighted linear regression, restricted cubic spline (RCS) techniques, and subgroup analyses.
The final sample included 4849 adults. Weighted linear regression confirmed a negative association between the WCS and the SII after adjusting for potential confounders (β = -16.72, 95 % CI: -34.29 to 0.85, P = 0.04). Subgroup analyses revealed that this association varied by obesity, gender, and age. Additionally, the association between the WCS duration and the SII was non-linear (P = 0.006) in adults with a weekday sleep duration of 7-8 h.
WCS can help mitigate the inflammatory burden associated with chronic sleep deprivation. WCS durations of 3 h and longer are particularly beneficial for adults who experience sleep deprivation on weekdays. The association between WCS and SII appears to be moderated by factors such as obesity, gender, and smoking status.
慢性睡眠剥夺普遍存在，并与包括炎症在内的有害健康结果相关。解决工作日睡眠不足的一个常见策略是周末补觉（WCS）。然而，通过全身免疫炎症指数（SII）量化的WCS对全身炎症的相关性仍未得到充分理解。
这项横断面分析检查了2017 - 2020年美国国家健康与营养检查调查（NHANES）队列的数据。为了探究WCS与SII之间的关系，我们采用了单变量分析、加权线性回归、受限立方样条（RCS）技术和亚组分析。
最终样本包括4849名成年人。加权线性回归证实，在调整潜在混杂因素后，WCS与SII之间存在负相关（β = -16.72，95% CI：-34.29至0.85，P = 0.04）。亚组分析显示，这种关联因肥胖、性别和年龄而异。此外，在工作日睡眠时间为7 - 8小时的成年人中，WCS持续时间与SII之间的关联是非线性的（P = 0.006）。
WCS有助于减轻与慢性睡眠剥夺相关的炎症负担。3小时及更长时间的WCS对平日睡眠不足的成年人特别有益。WCS与SII之间的关联似乎受到肥胖、性别和吸烟状况等因素的调节。
