Hong Si-Jie, Hong Li-Wei, He Xiao-Qin, Zhong Xiao-Hong, Zhang Xue-Qin
Department of Ultrasound, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361000, Fujian Province, China.
Ministry of Science and Education, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen 361000, Fujian Province, China.
Int J Med Sci. 2025 Feb 18;22(6):1246-1253. doi: 10.7150/ijms.107214. eCollection 2025.
Short sleep duration significantly increases the risk of liver disease. This study aims to investigate the relationship between weekend catch-up sleep (WCS) duration and hepatic steatosis in adults with varying weekday sleep durations in the United States. A cross-sectional analysis was conducted using adult participants from NHANES 2017 to March 2020. Anthropometry measurements, clinical features, biochemical parameters, and sleep duration (weekdays and weekends) were recorded. The controlled attenuation parameter (CAP) was utilized to evaluate the degree of liver steatosis. Student's t-test and Mann-Whitney U test were used for unpaired samples. Adjusted multi-variable logistic regression analysis was employed to evaluate the relationship between weekend catch-up sleep and hepatic steatosis. Weekend sleep habits varied based on age, obesity, race, education level, and marital status. Individuals with insufficient weekday sleep (<6 hours) and inadequate WCS (<1 hour) exhibited a significant increase in liver CAP values and a markedly higher probability of hepatic steatosis. In contrast WCS >1 hour effectively reduced the probability of hepatic steatosis. Individuals who adequately compensated for sleep on weekends had lower ratios of AST/ALT, total bilirubin and creatinine levels. Among different BMI populations, WCS was significantly associated with liver health in those with insufficient weekday sleep (<6 hours), whereas in individuals with adequate or sufficient weekday sleep (≥6 hours), WCS only reduced the progression of steatosis in individuals with normal BMI (<25). Adequate weekend catch-up sleep was associated with a lower the incidence of hepatic steatosis in individuals with insufficient weekday sleep duration.
睡眠时长过短会显著增加患肝病的风险。本研究旨在调查美国不同工作日睡眠时长的成年人的周末补觉（WCS）时长与肝脂肪变性之间的关系。使用2017年美国国家健康与营养检查调查（NHANES）至2020年3月的成年参与者进行横断面分析。记录人体测量学指标、临床特征、生化参数以及睡眠时长（工作日和周末）。采用受控衰减参数（CAP）评估肝脏脂肪变性程度。对不成对样本使用学生t检验和曼-惠特尼U检验。采用调整后的多变量逻辑回归分析评估周末补觉与肝脂肪变性之间的关系。周末睡眠习惯因年龄、肥胖、种族、教育水平和婚姻状况而异。工作日睡眠不足（<6小时）且周末补觉不足（<1小时）的个体肝脏CAP值显著升高，肝脂肪变性的概率明显更高。相比之下，周末补觉>1小时可有效降低肝脂肪变性的概率。周末充分补觉的个体谷草转氨酶/谷丙转氨酶比值、总胆红素和肌酐水平较低。在不同体重指数（BMI）人群中，周末补觉与工作日睡眠不足（<6小时）者的肝脏健康显著相关，而在工作日睡眠充足（≥6小时）的个体中，周末补觉仅能降低正常BMI（<25）个体的脂肪变性进展。工作日睡眠时长不足的个体中，充足的周末补觉与较低的肝脂肪变性发生率相关。
