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年轻医护人员慢性咳嗽的罕见病因——一例外源性类脂性肺炎!

Rare cause of chronic cough in a young healthcare worker - A case of exogenous lipoid pneumonia!

作者信息

Dikshit Nandini, Gupta Mansi, Nigam Neha, Nath Alok

机构信息

Department of Pulmonary Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

出版信息

J Family Med Prim Care. 2025 Jan;14(1):487-490. doi: 10.4103/jfmpc.jfmpc_1233_24. Epub 2025 Jan 13.

Abstract

Exogenous lipoid pneumonia (ELP) is a rarely reported entity caused by aspirating or inhaling fat or oil-containing substances. Clinically, patients present with subacute to chronic-onset non-specific symptoms such as cough, fever, breathlessness, and general malaise. In addition, lobar or multifocal interstitial and parenchymal infiltrates on chest imaging can mimic any other infectious etiology. Diagnosis of lipoid pneumonia is often missed or delayed in many cases and requires a high index of clinical suspicion. We report a case of a 36-year-old nursing officer who presented with a cough and right-sided pneumonia on chest imaging. She was being treated empirically with antitubercular therapy without any clinical response to the treatment. ELP was diagnosed after carefully evaluating the radiological findings, reviewing the clinical history, and finding supportive evidence of lipid-laden alveolar macrophages in her broncho-alveolar lavage fluid. It is vital to uphold a heightened clinical suspicion for non-infectious etiologies in non-resolving pneumonia and investigate the patient thoroughly before resorting to empirical treatments.

摘要

外源性类脂性肺炎(ELP)是一种由吸入含脂肪或油类物质引起的罕见疾病。临床上,患者表现为亚急性至慢性起病的非特异性症状,如咳嗽、发热、呼吸困难和全身不适。此外,胸部影像学上的大叶或多灶性间质及实质浸润可类似于任何其他感染性病因。在许多病例中,类脂性肺炎的诊断常常被漏诊或延误,需要高度的临床怀疑指数。我们报告一例36岁的护士,胸部影像学显示咳嗽和右侧肺炎。她接受了抗结核经验性治疗,但对治疗无任何临床反应。在仔细评估影像学表现、回顾临床病史并在其支气管肺泡灌洗液中发现充满脂质的肺泡巨噬细胞的支持性证据后,诊断为外源性类脂性肺炎。对于未缓解的肺炎,保持对非感染性病因的高度临床怀疑并在采取经验性治疗之前对患者进行全面检查至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0545/11844992/87dbcf02872f/JFMPC-14-487-g001.jpg

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