深海沉积物来源真菌 FS431 中的细胞毒性聚酮化合物

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Yuexiu District, Guangzhou 510070, China.

Molecules. 2019 Aug 22;24(17):3062. doi: 10.3390/molecules24173062.

Two new chromone-derived polyketides phaseolorins, G and H ( and ), and one new anthraquinone derivative, phaseolorin I (), together with three known compounds (-), were isolated from the deep-sea sediment-derived fungus FS431. The structures of the new compounds were determined by comprehensive analysis of their spectroscopic data, and the absolute configuration of was established by quantum chemical calculations of electron capture detection (ECD). All the isolated compounds (-) were tested for their in vitro cytotoxic activities against four human tumor cell lines, of which compound exhibited significant effect against MCF-7, HepG-2, and A549 tumor cell lines with IC values of 2.60, 2.55, and 4.64 µM, respectively.

从深海沉积物来源的真菌 FS431 中分离得到了两种新的色酮衍生聚酮化合物 G 和 H（和），以及一种新的蒽醌衍生物 phaseolorin I（），此外还分离得到了三种已知化合物（-）。通过综合分析它们的光谱数据确定了新化合物的结构，并通过电子俘获检测（ECD）的量子化学计算确定了的绝对构型。所有分离得到的化合物（-）都进行了体外细胞毒性活性测试，对四种人肿瘤细胞系进行了测试，其中化合物对 MCF-7、HepG-2 和 A549 肿瘤细胞系的抑制活性最强，IC 值分别为 2.60、2.55 和 4.64 µM。