Fornari Laurindo Lucas, Fornari Laurindo Lívia, Dogani Rodrigues Victória, da Silva Camarinha Oliveira Jéssica, Leme Boaro Beatriz, Cressoni Araújo Adriano, Landgraf Guiguer Elen, Rucco Penteado Detregiachi Claudia, Maria Cavallari Strozze Catharin Virgínia, Federighi Baisi Chagas Eduardo, Cavallari Strozze Catharin Vitor, Direito Rosa, Barbalho Sandra Maria
Department of Biochemistry and Pharmacology, School of Medicine, Faculdade de Medicina de Marília (FAMEMA), Marília, São Paulo, Brazil.
Department of Administration, Associate Degree in Hospital Management, Universidade de Marília (UNIMAR), Marília, São Paulo, Brazil.
Front Nutr. 2025 Feb 7;12:1502815. doi: 10.3389/fnut.2025.1502815. eCollection 2025.
Diabetes mellitus and dyslipidemia are significant health concerns that elevate the risk of cardiovascular disease and other metabolic disorders, necessitating effective management strategies. Recent research has highlighted the potential role of dietary fats, particularly seed oils, in influencing health outcomes in these conditions. This systematic review evaluates the impact of seed oils on lipid profiles, inflammatory and oxidative markers, and glycemic control in patients with diabetes and dyslipidemia. A comprehensive search across databases, including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, identified studies focusing on the effects of seed oils. The studies include randomized controlled, parallel-design, double-blind, placebo-controlled, and open-label studies published in English. The quality of the studies was assessed through a detailed review process, and data were extracted to evaluate the effects of seed oils on key metabolic markers. The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers. The findings suggest that seed oils may benefit in managing diabetes and dyslipidemia, although the results are sometimes inconsistent. This review provides valuable insights for dietary recommendations and therapeutic strategies, highlighting the need for further research to clarify the role of seed oils in metabolic health.
糖尿病和血脂异常是严重的健康问题，会增加心血管疾病和其他代谢紊乱的风险，因此需要有效的管理策略。最近的研究强调了膳食脂肪，特别是种子油，在影响这些疾病健康结果方面的潜在作用。本系统评价评估了种子油对糖尿病和血脂异常患者血脂谱、炎症和氧化标志物以及血糖控制的影响。通过对包括PubMed、Scopus、Web of Science、Cochrane图书馆和谷歌学术在内的数据库进行全面检索，确定了关注种子油作用的研究。这些研究包括以英文发表的随机对照、平行设计、双盲、安慰剂对照和开放标签研究。通过详细的评审过程评估研究质量，并提取数据以评估种子油对关键代谢标志物的影响。该评价纳入了11项研究，表明菜籽油、亚麻籽和芝麻籽来源的种子油可对血脂谱和血糖控制产生积极影响，同时可能调节氧化应激标志物。研究结果表明，种子油可能有助于控制糖尿病和血脂异常，尽管结果有时并不一致。本评价为饮食建议和治疗策略提供了有价值的见解，强调需要进一步研究以阐明种子油在代谢健康中的作用。
