Yanamala Poojitha, Youn Jeong-Yun, Thangavel Prakash, Moon Ju-Young, Lee Young-Chul
Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Republic of Korea.
Graduate School of Business Administration, Kwangwoon University, Nuri Hall, 20, Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea.
Curr Issues Mol Biol. 2025 Jan 31;47(2):88. doi: 10.3390/cimb47020088.
(Korean Cheonnyencho), a prickly pear cactus species, has garnered increased attention owing to its rich phytochemical composition and potential health benefits. In this study, the antioxidant and anti-cancer activities of a microwave-assisted aqueous extract derived from O. were investigated, and its phytochemical content was characterized. High-performance liquid chromatography (HPLC) was used to identify various bioactive compounds, including polyphenols, flavonoids, and other antioxidants known for their potential health-promoting properties. Furthermore, the individual compounds in the flavonoids were separated using the HPLC fractionation technique. The antioxidant potential of the aqueous extract was evaluated using 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. The results demonstrated the significant antioxidant activity of the extract, as evidenced by its ability to scavenge free radicals and effectively reduce oxidized molecules. The experiments involved treating colon cancer cells with varying concentrations of the extract (25 to 125 mg/mL) over a 24-h period, resulting in a remarkable dose-dependent inhibition of cell growth. Notably, this inhibitory effect was absent in HDFa cells, highlighting the potential selectivity of O. in targeting colon cancer cells.
（韩国天年草），一种仙人掌属植物，因其丰富的植物化学成分和潜在的健康益处而受到越来越多的关注。在本研究中，对从仙人掌属植物中提取的微波辅助水提取物的抗氧化和抗癌活性进行了研究，并对其植物化学成分进行了表征。采用高效液相色谱法（HPLC）鉴定了包括多酚、黄酮类化合物和其他具有潜在健康促进特性的抗氧化剂在内的各种生物活性化合物。此外，使用HPLC分级技术分离了黄酮类化合物中的各个化合物。使用2,2-二苯基-1-苦基肼自由基清除活性评估水提取物的抗氧化潜力。结果表明该提取物具有显著的抗氧化活性，其清除自由基和有效还原氧化分子的能力证明了这一点。实验包括在24小时内用不同浓度（25至125mg/mL）的提取物处理结肠癌细胞，结果导致细胞生长受到显著的剂量依赖性抑制。值得注意的是，这种抑制作用在人皮肤成纤维细胞中不存在，突出了仙人掌属植物在靶向结肠癌细胞方面的潜在选择性。
