Institute of Medicine, University of Gothenburg, Goteborg, Sweden
Norwegian Institute of Public Health, Oslo, Norway.
BMJ Open. 2021 Oct 1;11(10):e048980. doi: 10.1136/bmjopen-2021-048980.
To examine the associations between maternal vitamin D intake and childhood growth and risk of overweight up to 8 years. We further examined the effect modification by maternal prepregnancy body mass index (BMI).
Prospective population-based pregnancy cohort study.
The Norwegian Mother, Father and Child Cohort Study.
In total, 58 724 mothers and 66 840 singleton children, with information on maternal vitamin D intake during the pregnancy and minimum one postnatal anthropometric measurement.
Predicted weight and height growth trajectories and velocities from 1 month to 8 years, rapid growth during infancy and toddlerhood, and risk of overweight in preschool and school age.
Overall, maternal vitamin D intake was associated with lower weight trajectory, lower odds of rapid weight growth and higher odds of childhood overweight. In children of mothers with prepregnancy normal weight, maternal vitamin D intake was negatively associated with weight trajectory and lower OR of a rapid weight growth during the first year, compared with reference (<5 µg/day). Children of mothers with normal weight, with maternal vitamin D intakes of 10-15 and >15 µg/day, also had 0.86 (95% CI 0.77 to 0.97) and 0.88 (95% CI 0.79 to 0.99) lower odds for overweight at 3 years, compared with reference. In contrast, in children of mothers with prepregnancy overweight (BMI ≥25 kg/m), vitamin D intake was positively associated with weight trajectory. Children of mothers with overweight, with maternal vitamin D intake of 5-9.9 µg/day, also had (1.09 (95% CI 1.01 to 1.18) and 1.12 (95% CI 1.02 to 1.23)) higher odds for overweight at 5 years and 8 years, compared with reference.
Maternal vitamin D intake affects postnatal growth and is inversely associated with childhood overweight in children of mothers with normal weight. Associations between maternal vitamin D intake and child growth and risk of overweight varied by prepregnancy BMI.
研究母亲维生素 D 摄入量与儿童生长和超重风险之间的关系，时间跨度为 8 年。我们进一步研究了母亲孕前体重指数（BMI）对其的影响。
前瞻性人群基础妊娠队列研究。
挪威母婴儿童队列研究。
共有 58724 名母亲和 66840 名单胎儿童，他们提供了孕期维生素 D 摄入量信息和至少一次产后人体测量值。
1 个月至 8 岁时的体重和身高预测轨迹和生长速度、婴儿期和幼儿期的快速生长以及学龄前和学龄期超重的风险。
总的来说，母亲维生素 D 摄入量与较低的体重轨迹、较低的快速体重增长几率和较高的儿童超重几率有关。在母亲孕前体重正常的儿童中，与<5μg/d 参考组相比，母亲维生素 D 摄入量与体重轨迹呈负相关，且在第一年快速体重增长的几率较低。母亲孕前体重正常、维生素 D 摄入量为 10-15μg/d 和>15μg/d 的儿童，3 岁时超重的几率也分别降低了 0.86（95%CI 0.77-0.97）和 0.88（95%CI 0.79-0.99）。相比之下，在母亲孕前超重（BMI≥25kg/m2）的儿童中，维生素 D 摄入量与体重轨迹呈正相关。母亲孕前超重、维生素 D 摄入量为 5-9.9μg/d 的儿童，5 岁和 8 岁时超重的几率也分别升高了 1.09（95%CI 1.01-1.18）和 1.12（95%CI 1.02-1.23）。
母亲维生素 D 摄入量会影响产后生长，与母亲体重正常的儿童超重呈负相关。母亲维生素 D 摄入量与儿童生长和超重风险之间的关联因母亲孕前 BMI 而异。
