Janini Ana Cristina Padilha, Alves Débora Leticia Bittencourt Leite, Dos Santos Victor Augusto Benedicto, Moraes Brenda Fornazaro, da Silva Nilvan Alves, Barros-Costa Matheus, Martins Luciano Augusto Cano, Haiter Neto Francisco, Marciano Marina Angélica
Department of Restorative Dentistry - Endodontics, Piracicaba Dental School, Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
Department of Restorative Dentistry, School of Dentistry of Piracicaba, State University of Campinas, Av. Limeira, 901, Areião, Piracicaba, SP, CEP 13414-903, Brazil.
Clin Oral Investig. 2025 Feb 26;29(3):160. doi: 10.1007/s00784-025-06232-5.
The objective of this research was to evaluate the volumetric and surface stability in vitro, to different pH levels, of calcium silicate-based repair cements ready-to-use and powder/liquid exposed.
Sixty human teeth were retro-prepared to a depth of 3 mm and divided into two groups. The first group included powder/liquid cements Biodentine (Septodont, France) and MTA HP (Angelus, Brazil); the second group included ready-to-use cements Bio-C Repair (Angelus, Brazil) and ENDOCEM MTA (Maruchi, Republic of Korea). All samples were submerged in PBS solution with pH levels of 5, 7, and 12. Initially, the materials were evaluated for porosity, marginal adaptation, and volumetric change using micro-CT, and then re-evaluated after 7 and 30 days of exposure to PBS solution. The samples were characterized using SEM/EDS and RAMAN spectroscopy. Statistical evaluation was performed using ANOVA with a 5% significance level.
Bio-C Repair showed significant statistical differences (p < 0.05) at different pHs in 7 and 30 days compared to other materials, being greater in acidic medium. ENDOCEM, regardless of pH, at 30 days showed fewer voids when compared to other repair cements.
This micro-CT study demonstrated that regardless pH, the clinic presentation of calcium silicate-based materials ready-to-use showed higher and loss volumetric than powder/liquid materials at 30 days.
Under neutral pH conditions, calcium silicate-based materials are expected to maintain properties such as bioactivity and low solubility. However, in clinical situations involving infection and inflammation, pH variations can impact the physicochemical properties of these materials regardless of their clinical presentation.
本研究的目的是评估即用型和粉液型硅酸钙基修复水泥在体外不同pH水平下的体积稳定性和表面稳定性。
将60颗人牙倒预备至3mm深度并分为两组。第一组包括粉液型水泥Biodentine（法国Septodont公司）和MTA HP（巴西Angelus公司）；第二组包括即用型水泥Bio-C Repair（巴西Angelus公司）和ENDOCEM MTA（韩国Maruchi公司）。所有样本均浸泡在pH值分别为5、7和12的磷酸盐缓冲盐溶液（PBS）中。最初，使用微型计算机断层扫描（micro-CT）对材料的孔隙率、边缘适应性和体积变化进行评估，然后在暴露于PBS溶液7天和30天后重新评估。使用扫描电子显微镜/能谱仪（SEM/EDS）和拉曼光谱对样本进行表征。采用方差分析进行统计评估，显著性水平为5%。
与其他材料相比，Bio-C Repair在7天和30天的不同pH值下显示出显著的统计学差异（p < 0.05），在酸性介质中差异更大。ENDOCEM在30天时，无论pH值如何，与其他修复水泥相比孔隙较少。
这项微型计算机断层扫描研究表明，无论pH值如何，即用型硅酸钙基材料在30天时的临床表现显示出比粉液型材料更高的体积损失。
在中性pH条件下，硅酸钙基材料有望保持生物活性和低溶解性等特性。然而，在涉及感染和炎症的临床情况下，pH值变化会影响这些材料的物理化学性质，无论其临床表现如何。
