Yan Zi, Zhang Hongyu, Liu Shumei, Cui Jian, Zhu Yanfei, Zhao Guoxu, Liu Renwei, Cui Rongjun
Mudanjiang Collaborative Innovation Center for Development and Application of Northern Medicinal Resources, Mudanjiang, 157000, China.
Mudanjiang Medical University, Mudanjiang, 157000, China.
Lipids Health Dis. 2025 Feb 25;24(1):73. doi: 10.1186/s12944-025-02496-8.
Triglyceride glucose (TyG) index and atherogenic index of plasma (AIP) are indicators of insulin resistance. However, inadequate evidence indicates that the TyG index, AIP, and chronic pain are linked.
Data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004 were used. Directed acyclic graphs were used to identify 11 potential confounders. The TyG index and AIP were treated as continuous variables in the multivariate logistic regression models to assess their association with chronic pain. Furthermore, the nonlinear relationships between these indices and outcomes were investigated using restricted cubic spline plots. Subsequently, subgroup analyses were conducted for the sensitive populations. Receiver operating characteristic curves were used to compare the relationships between indices and outcomes. Ultimately, two sensitivity analyses were performed.
This study identified nonlinear associations between the TyG index, AIP, and chronic pain in 16,996,513 Americans. The odds ratio and 95% confidence interval for the TyG index (per 1 standard deviation increase) was 1.17 (1.02, 1.33), and for AIP (per 1 standard deviation increase) was 1.19 (1.07, 1.34). According to the subgroup analyses, the relationships between exposure and outcome were more pronounced in the non-diabetic population. The TyG index and AIP performed similarly in assessing chronic pain in ROC curves. Additionally, the results of the two sensitivity analyses matched the conclusions of the main study.
Nonlinear correlations between the TyG index, AIP, and chronic pain were identified among adults in the United States. This demonstrated that the TyG index and AIP displayed similar effectiveness in predicting the risk of chronic pain.
甘油三酯葡萄糖（TyG）指数和血浆致动脉粥样硬化指数（AIP）是胰岛素抵抗的指标。然而，证据不足表明TyG指数、AIP与慢性疼痛之间存在关联。
使用1999年至2004年美国国家健康与营养检查调查（NHANES）的数据。采用有向无环图来识别11个潜在混杂因素。在多变量逻辑回归模型中，将TyG指数和AIP作为连续变量，以评估它们与慢性疼痛的关联。此外，使用受限立方样条图研究这些指数与结局之间的非线性关系。随后，对敏感人群进行亚组分析。采用受试者工作特征曲线比较指数与结局之间的关系。最后，进行了两项敏感性分析。
本研究在美国16996513名成年人中发现了TyG指数、AIP与慢性疼痛之间的非线性关联。TyG指数（每增加1个标准差）的优势比和95%置信区间为1.17（1.02，1.33），AIP（每增加1个标准差）为1.19（1.07，1.34）。根据亚组分析，在非糖尿病人群中，暴露与结局之间的关系更为明显。TyG指数和AIP在ROC曲线中评估慢性疼痛时表现相似。此外，两项敏感性分析的结果与主要研究的结论一致。
在美国成年人中发现了TyG指数、AIP与慢性疼痛之间的非线性相关性。这表明TyG指数和AIP在预测慢性疼痛风险方面显示出相似的有效性。
