Wang Run, Tao Weijun, Cheng Xiaobing
Department of Cardiology, The Third People's Hospital of Hefei, Hefei, Anhui, China.
Front Cardiovasc Med. 2024 Jun 28;11:1379871. doi: 10.3389/fcvm.2024.1379871. eCollection 2024.
Oxidative stress is a known pathogenic mechanism in cardiovascular disease (CVD), yet the association between dietary antioxidants and CVD in the general population remains underexplored. This study leverages data from the National Health and Nutrition Examination Survey (NHANES) to investigate the association of a composite dietary antioxidant index with CVD in US adults.
Analyzing data from 25,997 adults (2011-2020 NHANES), we employed weighted generalized linear models, subgroup analysis, threshold effect analyses, and sensitivity analysis to assess the association between dietary antioxidants and CVD. Nonlinear associations were explored through a restricted cubic spline, with gender-specific stratification and threshold effect analysis to identify critical inflection points.
Increasing levels of the composite dietary antioxidant index corresponded with decreased CVD prevalence ( < 0.001). In all models, weighted generalized linear models revealed a consistent negative association between CVD prevalence. And in Model 3, Quartile 4 had a 29% lower CVD prevalence than Quartile 1[0.71 (0.59, 0.85), < 0.001]. Meanwhile, the findings of the unweighted logistic regression model demonstrated stability. Various characteristics such as sex, age, race, PIR, education, BMI, alcohol consumption, hypertension, hyperlipidemia, and diabetes did not influence this inverse association ( for interaction >0.05). Notably a nonlinear association was observed, with a significant inflection point at 3.05 among women.
This study demonstrates a strong negative association between the composite dietary antioxidant index and CVD prevalence, suggesting the potential protective role of dietary antioxidants. These findings underscore the need for prospective studies to further understand the impact of oxidative stress on cardiovascular health.
氧化应激是心血管疾病（CVD）中一种已知的致病机制，但一般人群中膳食抗氧化剂与CVD之间的关联仍未得到充分研究。本研究利用国家健康和营养检查调查（NHANES）的数据，调查美国成年人中复合膳食抗氧化剂指数与CVD之间的关联。
分析25997名成年人（2011 - 2020年NHANES）的数据，我们采用加权广义线性模型、亚组分析、阈值效应分析和敏感性分析来评估膳食抗氧化剂与CVD之间的关联。通过受限立方样条探索非线性关联，并进行性别特异性分层和阈值效应分析以确定关键拐点。
复合膳食抗氧化剂指数水平的升高与CVD患病率的降低相对应（<0.001）。在所有模型中，加权广义线性模型显示CVD患病率之间存在一致的负相关。在模型3中，四分位数4的CVD患病率比四分位数1低29%[0.71（0.59，0.85），<0.001]。同时，未加权逻辑回归模型的结果显示出稳定性。性别、年龄、种族、贫困收入比、教育程度、体重指数、饮酒、高血压、高脂血症和糖尿病等各种特征均未影响这种负相关（交互作用P>0.05）。值得注意的是，观察到一种非线性关联，女性中在3.05处有一个显著的拐点。
本研究表明复合膳食抗氧化剂指数与CVD患病率之间存在强烈的负相关，表明膳食抗氧化剂具有潜在的保护作用。这些发现强调了进行前瞻性研究以进一步了解氧化应激对心血管健康影响的必要性。
