Ioannou Petros, Ziogou Afroditi, Giannakodimos Alexios, Giannakodimos Ilias, Tsantes Andreas G, Samonis George
Department of Internal Medicine, University Hospital of Heraklion, 71110 Heraklion, Greece.
School of Medicine, University of Crete, 71003 Heraklion, Greece.
Antibiotics (Basel). 2025 Feb 1;14(2):140. doi: 10.3390/antibiotics14020140.
species are aerobic, Gram-negative, spherical-to-rod-shaped, psychrophilic bacteria that belong to the family. In spite of their uncommon manifestation in the general population, infections due to spp. are increasingly identified especially in immunocompromised individuals or patients with severe comorbidities.
This review aims to analyze all reported instances of spp. infections in humans, with an emphasis on data pertaining to epidemiology, microbiology, antimicrobial resistance, treatment strategies, and mortality outcomes.
A narrative review was performed through a literature search of PubMed/MedLine and Scopus databases.
In total, 12 articles offered data on 12 patients infected with spp. Their mean age was 33.41 years, while 63.64% of them were male. Immunosuppression was the predominant risk factor (33.3%). Bacteremia was the most commonly observed type of infection (41.6%), followed by meningitis, skin infection, and conjunctivitis. was the most usually identified species (33.3%). The pathogen exhibited sensitivity to most antimicrobials. The most widely administered antimicrobials included cephalosporins (70%), followed by aminopenicillins and vancomycin (40%, respectively). The clinical outcome depended primarily on the infection site; mortality rate was high (44.4%), especially in cases of bacteremia (50%).
Due to the potential of spp. to cause serious infection, clinicians and laboratory professionals should consider it in the differential diagnosis in patients with infections by Gram-negative spherical bacteria, particularly in patients with significant comorbidities and immunodeficiency, in order to accurately establish the diagnosis and proceed to the right treatment.
[细菌名称]属需氧、革兰氏阴性、球形至杆状的嗜冷菌，属于[细菌所属家族名称]。尽管它们在普通人群中表现不常见，但由[细菌名称]引起的感染越来越多地被发现，尤其是在免疫功能低下的个体或患有严重合并症的患者中。
本综述旨在分析所有已报道的人类感染[细菌名称]的病例，重点关注与流行病学、微生物学、抗菌药物耐药性、治疗策略和死亡率结果相关的数据。
通过对PubMed/MedLine和Scopus数据库进行文献检索进行叙述性综述。
总共12篇文章提供了12例感染[细菌名称]患者的数据。他们的平均年龄为33.41岁，其中63.64%为男性。免疫抑制是主要危险因素（33.3%）。菌血症是最常见的感染类型（41.6%），其次是脑膜炎、皮肤感染和结膜炎。[具体菌种名称]是最常鉴定出的菌种（33.3%）。该病原体对大多数抗菌药物敏感。使用最广泛的抗菌药物包括头孢菌素（70%），其次是氨基青霉素和万古霉素（分别为40%）。临床结果主要取决于感染部位；死亡率很高（44.4%），尤其是在菌血症病例中（50%）。
由于[细菌名称]有引起严重感染的可能性，临床医生和实验室专业人员在革兰氏阴性球形细菌感染患者的鉴别诊断中应考虑到它，特别是在患有严重合并症和免疫缺陷的患者中，以便准确做出诊断并进行正确治疗。
