Özcan Mustafa Soner, Aşcı Halil, Karabacak Pınar, Özden Eyyüp Sabri, Taner Rümeysa, Özmen Özlem, Tepebaşı Muhammet Yusuf, Çömlekçi Selçuk
Department of Anesthesiology and Reanimation, Faculty of Medicine, Suleyman Demirel University, Isparta 32260, Turkey.
Department of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta 32260, Turkey.
Bioengineering (Basel). 2025 Feb 14;12(2):183. doi: 10.3390/bioengineering12020183.
Pressure injuries are still an important health problem worldwide, although many therapies have been applied to date. This study aimed to determine the optimal duration of external application of a 10 kV/m direct current (DC, static) electric field in a pressure injury model in rats. Twelve male Wistar-Albino rats were divided into three groups: Grade-1, Grade-2, and Grade-3. Two round magnets were placed 4 h daily for one day in Grade-1, two days in Grade-2, and three days in Grade-3. Following wound formation, one rat from each group was designated the control, while the other rats were exposed to a 10 kV/m electric field for 15, 30, or 60 min. Histopathological improvements were observed after 15 and 30 min of application, whereas a sharp decrease in the gene expression of growth factors at 30 min revealed that 15 min of application was optimal overall. According to the results of this study, 15 min applications of an external 10 kV/m electric field are promising for providing satisfactory results in wound healing. Further studies should examine in greater detail the effects of electric fields on growth factors and the mechanisms underlying these responses.
尽管迄今为止已应用了许多疗法，但压力性损伤在全球范围内仍然是一个重要的健康问题。本研究旨在确定在大鼠压力性损伤模型中外加10 kV/m直流（DC，静态）电场的最佳持续时间。将12只雄性Wistar白化大鼠分为三组：1级、2级和3级。在1级组中，每天放置两块圆形磁铁4小时，持续1天；2级组持续2天；3级组持续3天。伤口形成后，每组指定1只大鼠作为对照，其余大鼠暴露于10 kV/m电场中15、30或60分钟。施加电场15分钟和30分钟后观察到组织病理学改善，而在30分钟时生长因子基因表达急剧下降，表明总体上15分钟的施加时间是最佳的。根据本研究结果，外加10 kV/m电场15分钟的应用有望在伤口愈合方面提供令人满意的结果。进一步的研究应更详细地研究电场对生长因子的影响以及这些反应的潜在机制。
