N-亚硝基西咪替丁对培养的人淋巴细胞姐妹染色单体交换的诱导作用及其被化合物的抑制作用。
Induction of sister-chromatid exchanges by N-nitrosocimetidine in cultured human lymphocytes and its inhibition by chemical compounds.
作者信息
Inoue K, Shibata T, Kosaka H, Uozumi M, Tsuda S, Abe T
出版信息
Mutat Res. 1985 Apr-May;156(1-2):117-21. doi: 10.1016/0165-1218(85)90014-x.
The effect of nitrosocimetidine (NC) on the frequency of sister-chromatid exchanges (SCEs) in human lymphocytes has been studied. The frequency of SCEs induced by a 1-h exposure to 2.6 X 10(-4) M NC was 4-fold greater than that in the solvent control. A 72-h exposure to NC had a similar dose-related effect. We also examined the effect of the sulfhydryl compounds cysteine, cysteamine, cystamine and glutathione, the reducing agent dithionite, and vitamins C and E on the NC-induced SCEs. None of these compounds induced SCEs. Cysteine, cysteamine, and cystamine significantly reduced the number of NC-induced SCEs, and the others did not.
已研究了亚硝基西咪替丁（NC）对人淋巴细胞中姐妹染色单体交换（SCE）频率的影响。暴露于2.6×10⁻⁴M NC 1小时所诱导的SCE频率比溶剂对照高4倍。暴露于NC 72小时有类似的剂量相关效应。我们还研究了巯基化合物半胱氨酸、半胱胺、胱胺和谷胱甘肽、还原剂连二亚硫酸盐以及维生素C和E对NC诱导的SCE的影响。这些化合物均未诱导SCE。半胱氨酸、半胱胺和胱胺显著减少了NC诱导的SCE数量，而其他化合物则没有。
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