Inoue K, Shibata T, Kosaka H, Uozumi M, Tsuda S, Abe T
Mutat Res. 1985 Apr-May;156(1-2):117-21. doi: 10.1016/0165-1218(85)90014-x.
The effect of nitrosocimetidine (NC) on the frequency of sister-chromatid exchanges (SCEs) in human lymphocytes has been studied. The frequency of SCEs induced by a 1-h exposure to 2.6 X 10(-4) M NC was 4-fold greater than that in the solvent control. A 72-h exposure to NC had a similar dose-related effect. We also examined the effect of the sulfhydryl compounds cysteine, cysteamine, cystamine and glutathione, the reducing agent dithionite, and vitamins C and E on the NC-induced SCEs. None of these compounds induced SCEs. Cysteine, cysteamine, and cystamine significantly reduced the number of NC-induced SCEs, and the others did not.
已研究了亚硝基西咪替丁（NC）对人淋巴细胞中姐妹染色单体交换（SCE）频率的影响。暴露于2.6×10⁻⁴M NC 1小时所诱导的SCE频率比溶剂对照高4倍。暴露于NC 72小时有类似的剂量相关效应。我们还研究了巯基化合物半胱氨酸、半胱胺、胱胺和谷胱甘肽、还原剂连二亚硫酸盐以及维生素C和E对NC诱导的SCE的影响。这些化合物均未诱导SCE。半胱氨酸、半胱胺和胱胺显著减少了NC诱导的SCE数量，而其他化合物则没有。
