Gomez-Arroyo S, Souza V
Mutat Res. 1985 Jun;156(3):233-8. doi: 10.1016/0165-1218(85)90068-0.
Sister-chromatid exchanges (SCEs) in human lymphocytes were studied using the FPG technique in order to determine the cytogenetic effect of furfural and furfuryl alcohol. The induction of SCEs was also investigated in workers occupationally exposed to these solvents that are commonly used in the manufacture of furoic resins. The results obtained from the in vitro treatments show that furfural increased the number of SCEs, while furfuryl alcohol did not. In exposed workers, neither of these solvents increased the spontaneous frequency of SCEs per metaphase.
为了确定糠醛和糠醇的细胞遗传学效应，采用FPG技术对人淋巴细胞中的姐妹染色单体交换（SCEs）进行了研究。还对职业性接触这些常用于制造糠醛树脂的溶剂的工人的SCEs诱导情况进行了调查。体外处理获得的结果表明，糠醛增加了SCEs的数量，而糠醇则没有。在接触溶剂的工人中，这两种溶剂均未增加每个中期SCEs的自发频率。
