Zhao Haitao, Wang Yan, Li Jiaxuan, Li Nianlong, Zhou Wenhui, Wang Chengliang, Li Baoguo
Shaanxi Provincial Field Observation & Research Station for Golden Monkey, Giant Panda and Biodiversity, Shaanxi Institute of Zoology, Xi'an 710032, China.
Shaanxi Key Laboratory for Animal Conservation, Northwest University, Xi'an 710069, China.
Biology (Basel). 2025 Feb 3;14(2):156. doi: 10.3390/biology14020156.
Post-traumatic stress disorder (PTSD) is a severe psychiatric disorder, affecting approximately 25-35% of individuals exposed to significant psychological trauma. Despite extensive research, the underlying biological mechanisms of PTSD remain poorly understood, and the effectiveness of trauma-focused psychotherapeutic interventions is limited. To date, animal studies investigating trauma responses have primarily relied on rodent models, with the potential contributions of non-human primates relatively neglected. In this study, matched-control observations were employed to examine maternal caregiving behaviors, prosocial interactions, and responses to alarm calls in free-ranging golden snub-nosed monkeys () before and after an infanticide event. Results indicated a significant decrease in prosocial behaviors among some mothers, accompanied by significant increases in caregiving behaviors, heightened responsiveness to alarm calls, and indications of low mood. These findings provide evidence of trauma-related behavioral changes in golden snub-nosed monkeys, underscoring their utility as a model for studying PTSD given the similarity to trauma responses observed in humans. Overall, this study provides a foundation for further investigation into the evolutionary and biological aspects of PTSD, as well as the interactions between species-specific trauma responses. Future research should explore the use of non-human primate models to deepen our understanding of PTSD mechanisms.
创伤后应激障碍（PTSD）是一种严重的精神疾病，影响着约25%-35%遭受重大心理创伤的个体。尽管进行了广泛研究，但PTSD的潜在生物学机制仍知之甚少，且以创伤为重点的心理治疗干预措施的效果有限。迄今为止，研究创伤反应的动物研究主要依赖啮齿动物模型，非人类灵长类动物的潜在贡献相对被忽视。在本研究中，采用配对对照观察法，研究了野生川金丝猴在杀婴事件前后的母性照料行为、亲社会互动以及对警报叫声的反应。结果表明，一些母亲的亲社会行为显著减少，同时照料行为显著增加，对警报叫声的反应性增强，且有情绪低落的迹象。这些发现为川金丝猴创伤相关行为变化提供了证据，鉴于其与人类观察到的创伤反应相似，强调了它们作为研究PTSD模型的实用性。总体而言，本研究为进一步探究PTSD的进化和生物学方面以及物种特异性创伤反应之间的相互作用奠定了基础。未来的研究应探索使用非人类灵长类动物模型来加深我们对PTSD机制的理解。
