Li Changzhen, Tang Feng, Xi Lei, Wang Xiaomei
Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Front Public Health. 2025 Feb 13;13:1512403. doi: 10.3389/fpubh.2025.1512403. eCollection 2025.
To investigate the association between meteorological factors and common uropathogens in children with urinary tract infections (UTIs) and assesses the potential influence of weather conditions on pediatric UTIs.
Analyze the demographic and uropathogen characteristics from children with culture-proven UTIs and its correlation with meteorological factors.
2,411 data from infants and children with UTIs in a children's hospital from 2016 to 2021 were retrospectively analyzed. A correlation analysis was conducted to investigate the relationship between the monthly detection number of uropathogens and meteorological factors.
Multiple linear stepwise regression analyses showed a positive correlation between monthly average temperature, precipitation volume, sunshine hours, monthly total number of uropathogens, and the number of and . was predominant in <12-month-old children, while was dominant in the 3-18-year age category. showed a higher prevalence in girls, while was more prevalent in boys. exhibited resistance rates of >40% to second-or third-generation cephalosporins in multiple age groups. showed high resistance rates to tetracyclines, fluoroquinolones, erythromycin, ampicillin, and penicillin, while displayed higher sensitivity to cephalosporin-sulbactam and amikacin, but higher resistance rates to cefazolin and ceftazidime.
This study reveals the association between meteorological factors and uropathogens in children with UTIs, as well as the distribution, age-related characteristics, gender differences and antibiotic resistance profiles of pathogenic bacteria. These findings inform the development of targeted strategies for UTI prevention and treatment based on uropathogenic characteristics and meteorological conditions.
探讨气象因素与尿路感染（UTIs）患儿常见尿路病原体之间的关联，并评估天气状况对儿童UTIs的潜在影响。
分析经培养证实患有UTIs的儿童的人口统计学和尿路病原体特征及其与气象因素的相关性。
回顾性分析2016年至2021年一家儿童医院2411例婴幼儿和儿童UTIs的数据。进行相关性分析以研究尿路病原体每月检测数量与气象因素之间的关系。
多元线性逐步回归分析显示月平均温度、降水量、日照时数、尿路病原体每月总数以及[具体细菌1]和[具体细菌2]的数量之间呈正相关。[具体细菌1]在12个月以下儿童中占主导地位，而[具体细菌2]在3至18岁年龄组中占主导。[具体细菌1]在女孩中患病率较高，而[具体细菌2]在男孩中更普遍。[具体细菌1]在多个年龄组中对第二代或第三代头孢菌素的耐药率>40%。[具体细菌2]对四环素、氟喹诺酮类、红霉素、氨苄西林和青霉素显示出高耐药率，而[具体细菌3]对头孢哌酮舒巴坦和阿米卡星敏感性较高，但对头孢唑林和头孢他啶耐药率较高。
本研究揭示了气象因素与UTIs患儿尿路病原体之间的关联，以及病原菌的分布、年龄相关特征、性别差异和抗生素耐药谱。这些发现为基于尿路致病特征和气象条件制定UTI预防和治疗的针对性策略提供了依据。
