• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

具有甲型流感（H1N1）pdm09免疫力的雪貂对甲型流感（H5N1）的免疫反应。

Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity.

作者信息

Le Sage Valerie, Werner Bailee D, Merrbach Grace A, Petnuch Sarah E, O'Connell Aoife K, Simmons Holly C, McCarthy Kevin R, Reed Douglas S, Moncla Louise H, Bhavsar Disha, Krammer Florian, Crossland Nicholas A, McElroy Anita K, Duprex W Paul, Lakdawala Seema S

出版信息

Emerg Infect Dis. 2025 Mar;31(3):477-487. doi: 10.3201/eid3103.241485.

DOI:10.3201/eid3103.241485
PMID:40023796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11878318/
Abstract

The emergence of highly pathogenic avian influenza A(H5N1) virus in dairy cattle herds across the United States in 2024 caused several human infections. Understanding the risk for spillover infections into humans is crucial for protecting public health. We investigated whether immunity from influenza A(H1N1)pdm09 (pH1N1) virus would provide protection from death and severe clinical disease among ferrets intranasally infected with H5N1 virus from dairy cows from the 2024 outbreak. We observed differential tissue tropism among pH1N1-immune ferrets. pH1N1-immune ferrets also had little H5N1 viral dissemination to organs outside the respiratory tract and much less H5N1 virus in nasal secretions and the respiratory tract than naive ferrets. In addition, ferrets with pH1N1 immunity produced antibodies that cross-reacted with H5N1 neuraminidase protein. Taken together, our results suggest that humans with immunity to human seasonal influenza viruses may experience milder disease from the 2024 influenza A(H5N1) virus strain.

摘要

2024年，高致病性甲型禽流感（H5N1）病毒在美国各地奶牛群中出现，导致数起人类感染病例。了解病毒溢出感染人类的风险对于保护公众健康至关重要。我们调查了甲型流感（H1N1）pdm09（pH1N1）病毒产生的免疫力是否能保护雪貂免受2024年疫情中感染H5N1病毒的奶牛鼻腔感染后的死亡和严重临床疾病。我们观察到pH1N1免疫雪貂之间存在不同的组织嗜性。与未免疫的雪貂相比，pH1N1免疫雪貂的H5N1病毒向呼吸道外器官的传播也很少，鼻腔分泌物和呼吸道中的H5N1病毒也少得多。此外，具有pH1N1免疫力的雪貂产生了与H5N1神经氨酸酶蛋白发生交叉反应的抗体。综上所述，我们的结果表明，对人类季节性流感病毒具有免疫力的人感染2024年甲型（H5N1）流感病毒后，病情可能会较轻。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/fecf0188f884/24-1485-F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/38560b2551aa/24-1485-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/3772c7af61f8/24-1485-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/c0bbca3b0250/24-1485-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/81f3c3bebeb2/24-1485-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/2d79aa07d174/24-1485-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/5078dacd3b3e/24-1485-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/29ca6ad0d930/24-1485-F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/fecf0188f884/24-1485-F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/38560b2551aa/24-1485-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/3772c7af61f8/24-1485-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/c0bbca3b0250/24-1485-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/81f3c3bebeb2/24-1485-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/2d79aa07d174/24-1485-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/5078dacd3b3e/24-1485-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/29ca6ad0d930/24-1485-F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f81/11878318/fecf0188f884/24-1485-F8.jpg

相似文献

1
Influenza A(H5N1) Immune Response among Ferrets with Influenza A(H1N1)pdm09 Immunity.具有甲型流感（H1N1）pdm09免疫力的雪貂对甲型流感（H5N1）的免疫反应。
Emerg Infect Dis. 2025 Mar;31(3):477-487. doi: 10.3201/eid3103.241485.
2
Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model.既往甲型H1N1pdm09流感病毒感染对雪貂模型中人类甲型H5N1 2.3.4.4b分支病毒发病机制及传播的影响
Emerg Infect Dis. 2025 Mar;31(3):458-466. doi: 10.3201/eid3103.241489.
3
Pre-existing H1N1 immunity reduces severe disease with bovine H5N1 influenza virus.预先存在的甲型H1N1流感免疫力可降低感染牛源H5N1流感病毒后的严重疾病发生率。
bioRxiv. 2024 Oct 23:2024.10.23.619881. doi: 10.1101/2024.10.23.619881.
4
M2SR, a novel live influenza vaccine, protects mice and ferrets against highly pathogenic avian influenza.新型活流感疫苗M2SR可保护小鼠和雪貂免受高致病性禽流感的侵害。
Vaccine. 2017 Jul 24;35(33):4177-4183. doi: 10.1016/j.vaccine.2017.06.039. Epub 2017 Jun 28.
5
The 2009 pandemic H1N1 virus induces anti-neuraminidase (NA) antibodies that cross-react with the NA of H5N1 viruses in ferrets.2009 年大流行的 H1N1 病毒诱导产生的抗神经氨酸酶（NA）抗体可与雪貂体内的 H5N1 病毒的 NA 发生交叉反应。
Vaccine. 2012 Mar 28;30(15):2516-22. doi: 10.1016/j.vaccine.2012.01.090. Epub 2012 Feb 11.
6
Cross-Reactive Neuraminidase-Inhibiting Antibodies Elicited by Immunization with Recombinant Neuraminidase Proteins of H5N1 and Pandemic H1N1 Influenza A Viruses.用H5N1和甲型H1N1大流行性流感病毒的重组神经氨酸酶蛋白免疫引发的交叉反应性神经氨酸酶抑制抗体。
J Virol. 2015 Jul;89(14):7224-34. doi: 10.1128/JVI.00585-15. Epub 2015 May 6.
7
Neuraminidase-Inhibiting Antibody Titers Correlate with Protection from Heterologous Influenza Virus Strains of the Same Neuraminidase Subtype.神经氨酸酶抑制抗体滴度与对同一神经氨酸酶亚型的异源流感病毒株的保护作用相关。
J Virol. 2018 Aug 16;92(17). doi: 10.1128/JVI.01006-18. Print 2018 Sep 1.
8
Prior infection with an H1N1 swine influenza virus partially protects pigs against a low pathogenic H5N1 avian influenza virus.先前感染H1N1猪流感病毒可使猪对低致病性H5N1禽流感病毒产生部分保护作用。
Vaccine. 2009 Oct 23;27(45):6330-9. doi: 10.1016/j.vaccine.2009.03.021.
9
H1N1, but not H3N2, influenza A virus infection protects ferrets from H5N1 encephalitis.甲型 H1N1 流感病毒感染可保护雪貂免受 H5N1 脑炎，而非 H3N2 流感病毒。
J Virol. 2014 Mar;88(6):3077-91. doi: 10.1128/JVI.01840-13. Epub 2013 Dec 26.
10
Tropism and Infectivity of a Seasonal A(H1N1) and a Highly Pathogenic Avian A(H5N1) Influenza Virus in Primary Differentiated Ferret Nasal Epithelial Cell Cultures.季节性 A(H1N1)和高致病性禽流感 A(H5N1)流感病毒在原代分化雪貂鼻上皮细胞培养物中的趋向性和感染性。
J Virol. 2019 May 1;93(10). doi: 10.1128/JVI.00080-19. Print 2019 May 15.

引用本文的文献

1
Human infections with highly pathogenic avian influenza A(H5N1) viruses in the United States from March 2024 to May 2025.2024年3月至2025年5月期间美国人类感染高致病性甲型禽流感（H5N1）病毒的情况。
Nat Med. 2025 Jul 25. doi: 10.1038/s41591-025-03905-2.
2
Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like properties.从奶牛中分离出的B3.13基因型甲型H5N1流感病毒在实验室模型中表现出高致病性，但仍保留类似禽病毒的特性。
Nat Commun. 2025 Jul 23;16(1):6771. doi: 10.1038/s41467-025-61757-3.
3
Highly Pathogenic Avian Influenza (H5N1) Clade 2.3.4.4b in Cattle: A Rising One Health Concern.

本文引用的文献

1
Targets of influenza human T-cell response are mostly conserved in H5N1.甲型流感病毒H5N1亚型中人类T细胞应答的靶点大多是保守的。
mBio. 2025 Feb 5;16(2):e0347924. doi: 10.1128/mbio.03479-24. Epub 2024 Dec 23.
2
Transmission of a human isolate of clade 2.3.4.4b A(H5N1) virus in ferrets.2.3.4.4b进化枝甲型流感病毒（H5N1）人源分离株在雪貂中的传播
Nature. 2024 Dec;636(8043):705-710. doi: 10.1038/s41586-024-08246-7. Epub 2024 Oct 28.
3
A human isolate of bovine H5N1 is transmissible and lethal in animal models.一种源自牛的H5N1病毒的人类分离株在动物模型中具有传染性且致死性。
牛身上的高致病性禽流感（H5N1）2.3.4.4b分支：一个日益严重的“同一健康”问题
Animals (Basel). 2025 Jul 3;15(13):1963. doi: 10.3390/ani15131963.
4
Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle.美国高致病性H5N1禽流感：近期的传入及向牛群的传播
Npj Viruses. 2025 Jul 5;3(1):54. doi: 10.1038/s44298-025-00138-5.
5
A replicating recombinant vesicular stomatitis virus model for dairy cattle H5N1 influenza virus glycoprotein evolution.一种用于研究奶牛H5N1流感病毒糖蛋白进化的复制型重组水疱性口炎病毒模型。
J Virol. 2025 Jun 4:e0038925. doi: 10.1128/jvi.00389-25.
6
Ocular infectivity and replication of a clade 2.3.4.4b A(H5N1) influenza virus associated with human conjunctivitis in a dairy farm worker in the USA: an in-vitro and ferret study.美国一名奶牛场工人感染与人类结膜炎相关的2.3.4.4b进化分支A(H5N1)流感病毒后的眼部传染性及复制情况：一项体外和雪貂研究
Lancet Microbe. 2025 Jul;6(7):101070. doi: 10.1016/j.lanmic.2024.101070. Epub 2025 Mar 17.
7
Effect of Prior Influenza A(H1N1)pdm09 Virus Infection on Pathogenesis and Transmission of Human Influenza A(H5N1) Clade 2.3.4.4b Virus in Ferret Model.既往甲型H1N1pdm09流感病毒感染对雪貂模型中人类甲型H5N1 2.3.4.4b分支病毒发病机制及传播的影响
Emerg Infect Dis. 2025 Mar;31(3):458-466. doi: 10.3201/eid3103.241489.
Nature. 2024 Dec;636(8043):711-718. doi: 10.1038/s41586-024-08254-7. Epub 2024 Oct 28.
4
The global H5N1 influenza panzootic in mammals.哺乳动物中全球H5N1流感大流行。
Nature. 2025 Jan;637(8045):304-313. doi: 10.1038/s41586-024-08054-z. Epub 2024 Sep 24.
5
Intranasal administration of octavalent next-generation influenza vaccine elicits protective immune responses against seasonal and pre-pandemic viruses.鼻内接种八价下一代流感疫苗可引发针对季节性和大流行前病毒的保护性免疫应答。
J Virol. 2024 Sep 17;98(9):e0035424. doi: 10.1128/jvi.00354-24. Epub 2024 Aug 22.
6
The panzootic spread of highly pathogenic avian influenza H5N1 sublineage 2.3.4.4b: a critical appraisal of One Health preparedness and prevention.高致病性禽流感 H5N1 亚系 2.3.4.4b 的泛发性传播：对“同一健康”防备和预防的批判性评估。
Lancet Infect Dis. 2024 Dec;24(12):e774-e781. doi: 10.1016/S1473-3099(24)00438-9. Epub 2024 Aug 9.
7
Pathogenicity and transmissibility of bovine H5N1 influenza virus.牛源 H5N1 流感病毒的致病性和传染性。
Nature. 2024 Sep;633(8029):426-432. doi: 10.1038/s41586-024-07766-6. Epub 2024 Jul 8.
8
Potential pandemic risk of circulating swine H1N2 influenza viruses.流行猪H1N2流感病毒的潜在大流行风险。
Nat Commun. 2024 Jun 13;15(1):5025. doi: 10.1038/s41467-024-49117-z.
9
Development of a nucleoside-modified mRNA vaccine against clade 2.3.4.4b H5 highly pathogenic avian influenza virus.针对 2.3.4.4b 谱系 H5 高致病性禽流感病毒的核苷修饰 mRNA 疫苗的研制。
Nat Commun. 2024 May 23;15(1):4350. doi: 10.1038/s41467-024-48555-z.
10
Highly Pathogenic Avian Influenza A(H5N1) Virus Infection in a Dairy Farm Worker.一名奶农感染高致病性甲型禽流感（H5N1）病毒
N Engl J Med. 2024 Jun 6;390(21):2028-2029. doi: 10.1056/NEJMc2405371. Epub 2024 May 3.