苏丹东部青少年中糖尿病前期的患病率及相关因素：一项基于社区的横断面研究。

Prevalence of and factors associated with pre-diabetes among adolescents in Eastern Sudan: a community-based cross-sectional study.

机构信息

Gadarif University, Gadarif, Sudan.

Department of Pediatrics, Qassim University, Buraidah, Saudi Arabia

出版信息

BMJ Open. 2024 Oct 9;14(10):e086197. doi: 10.1136/bmjopen-2024-086197.

DOI:10.1136/bmjopen-2024-086197

PMID:39384233

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11481266/

Abstract

OBJECTIVES

There is an increasing trend of pre-diabetes and diabetes mellitus (DM) among adolescents, and sub-Saharan Africa is no exception. However, few published data on pre-diabetes among adolescents in Sudan exist. We aimed to investigate the prevalence of and factors associated with pre-diabetes among adolescents in Eastern Sudan.

DESIGN

A community-based cross-sectional study was conducted from August to October 2023.

SETTINGS

This community-based study was conducted in Gadarif city, the capital of Gadarif state, Eastern Sudan.

PARTICIPANTS

Adolescents (within the ages of 10-19 years).

MAIN OUTCOME MEASURES

A questionnaire was used to collect socio-demographic information. Anthropometric and glycated haemoglobin (HbA1c) measurements were performed in accordance with standard procedures. Multivariate logistic regression analysis was performed.

RESULTS

Of the 387 enrolled adolescents, 207 (53.5%) were female and 180 (46.5%) were male. The median (IQR) age was 14.0 (12.0-16.0) years. 39.5% of the participants' fathers were employed. The median (IQR) HbA1c was 5.5% (5.2%-5.8%). One-third (32.6%) of the adolescents had pre-diabetes or DM. Of the participants, 67.4%, 30.0% and 2.6% had no DM, pre-diabetes or type 2 DM, respectively. In the univariate analysis, the father's employment (OR=1.60, 95% CI=1.03 to 2.50) was associated with increased odds of pre-diabetes; age, sex, parents' education, the mother's occupation, body mass index z-score, cigarette smoking and a family history of DM were not associated with pre-diabetes. In the multivariate analysis, the father's employment (adjusted OR=1.70, 95% CI=1.03 to 2.50) was associated with increased odds of pre-diabetes.

CONCLUSION

Pre-diabetes is a significant public health problem among adolescents in Eastern Sudan. The introduction of early screening programmes for pre-diabetes at the community level is recommended to halt the progression of pre-diabetes to DM and to deal with existing DM among adolescents.

摘要

目的

青少年中糖尿病前期和糖尿病（DM）的发病率呈上升趋势，撒哈拉以南非洲也不例外。然而，苏丹关于青少年糖尿病前期的发表数据很少。我们旨在研究苏丹东部青少年糖尿病前期的患病率和相关因素。

设计

这是一项 2023 年 8 月至 10 月期间在苏丹东部加达里夫市进行的基于社区的横断面研究。

地点

这项基于社区的研究在加达里夫州首府加达里夫市进行。

参与者

青少年（年龄在 10-19 岁之间）。

主要观察指标

调查问卷收集社会人口统计学信息。根据标准程序进行人体测量和糖化血红蛋白（HbA1c）测量。进行多变量逻辑回归分析。

结果

在纳入的 387 名青少年中，有 207 名（53.5%）为女性，180 名（46.5%）为男性。参与者的中位（IQR）年龄为 14.0（12.0-16.0）岁。39.5%的父亲有工作。中位（IQR）HbA1c 为 5.5%（5.2%-5.8%）。三分之一（32.6%）的青少年患有糖尿病前期或 DM。在参与者中，分别有 67.4%、30.0%和 2.6%的人没有 DM、糖尿病前期或 2 型 DM。在单因素分析中，父亲的就业状况（OR=1.60，95%CI=1.03 至 2.50）与糖尿病前期的患病几率增加相关；年龄、性别、父母的教育程度、母亲的职业、体重指数 z 分数、吸烟和 DM 的家族史与糖尿病前期无关。在多因素分析中，父亲的就业状况（调整后的 OR=1.70，95%CI=1.03 至 2.50）与糖尿病前期的患病几率增加相关。