Shiga J, Mori W
Acta Pathol Jpn. 1985 Jan;35(1):103-7. doi: 10.1111/j.1440-1827.1985.tb02209.x.
Severe pathological fibrotic change of rabbits treated with endotoxin was produced. The liver of the rabbits that died within 14 days showed severe architectural distortion through wide fibrotic band which could be called morphologically post necrotic liver cirrhosis. On the other hand, in the liver of the rabbits that remained alive more than 14 days thin septal nodular structures were observed. This experimental model is proposed as a tool for the further study of the pathogenesis of human liver cirrhosis.
制造了内毒素处理的兔子严重病理性纤维化改变。在14天内死亡的兔子肝脏显示出通过宽纤维化带的严重结构扭曲，这在形态学上可称为坏死后肝硬化。另一方面，在存活超过14天的兔子肝脏中观察到薄的间隔结节结构。该实验模型被提议作为进一步研究人类肝硬化发病机制的工具。
