Darlu P, Cavalli-Sforza L L
Am J Hum Genet. 1985 May;37(3):581-90.
One can extend exclusion of ancestry beyond paternity: for example, to grandparents or other types of ancestors. Naturally, the probability of successful exclusion is smaller for more remote ancestors. The case that we have especially considered is that of exclusion on the basis of grandparents, of which there have been recent applications. A method of calculating the average probability of exclusion, P, in such situations is developed and applied to different genetic systems including DNA polymorphisms available today. As usual, multiallelic genes like HLA are by far the most informative, but a substantial number of other genes should also be tested to reach a reasonable probability of exclusion. The effect of inbreeding on P is demonstrated to be negligible.
例如祖父母或其他类型的祖先。自然地，对于更遥远的祖先，成功排除的概率较小。我们特别考虑的情况是基于祖父母的排除，近期已有相关应用。本文开发了一种计算此类情况下平均排除概率P的方法，并将其应用于包括当今可用的DNA多态性在内的不同遗传系统。与往常一样，像HLA这样的多等位基因是目前最具信息量的，但也应测试大量其他基因，以达到合理的排除概率。近亲繁殖对P的影响被证明可忽略不计。
