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大鼠小肠的淋巴液流动、淋巴蛋白浓度及蛋白输出量

Lymph flow, lymph protein concentration, and protein output from rat small intestine.

作者信息

Lee J S

出版信息

Am J Physiol. 1985 Jun;248(6 Pt 1):G670-5. doi: 10.1152/ajpgi.1985.248.6.G670.

DOI:10.1152/ajpgi.1985.248.6.G670
PMID:4003547
Abstract

Lymph flow (JL), lymph protein concentration (CL), and protein output (JP) from the main intestinal lymph duct were determined. The basal JL from the mesenteric pedicle alone was the same as that from the mesenteric pedicle attached with a segment of the nonabsorbing intestine, indicating that the basal JL does not originate from the intestine but is totally from the region of the mesenteric pedicle. The basal CL was 3.5-3.8 g/100 ml. When the intestine was absorbing water, JL increased and CL decreased, but JP increased above the basal JP in the initial 20 min of water absorption and then decreased progressively with time. Furthermore, it was estimated that CL in the "excess lymph" (formed during water absorption) was 1.4 +/- 0.2 g/100 ml in the initial 10 min of water absorption and was zero or nearly so in the later periods. From this and other evidence, it is concluded that under various conditions without net water absorption rat small intestine does not produce lymph and that during water absorption there is no significant increase in capillary permeability or capillary filtration. Therefore, the excess lymph could be mostly derived from the fluid absorbed from the lumen of the intestine.

摘要

测定了来自主肠淋巴管的淋巴流量(JL)、淋巴蛋白浓度(CL)和蛋白输出量(JP)。仅来自肠系膜蒂的基础JL与附着有一段不吸收肠段的肠系膜蒂的基础JL相同,这表明基础JL并非起源于肠道,而是完全来自肠系膜蒂区域。基础CL为3.5 - 3.8 g/100 ml。当肠道吸收水分时,JL增加而CL降低,但在吸水的最初20分钟内JP高于基础JP,随后随时间逐渐下降。此外,据估计,在吸水最初10分钟内“多余淋巴”(吸水过程中形成)中的CL为1.4±0.2 g/100 ml,后期则为零或接近零。基于此及其他证据得出结论,在无净吸水的各种条件下,大鼠小肠不产生淋巴,且在吸水过程中毛细血管通透性或毛细血管滤过无显著增加。因此,多余淋巴可能主要源自从肠腔吸收的液体。

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