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淋巴管阻塞大鼠肠淋巴管内的淋巴压力

Lymph pressure in rat intestinal lymph duct with lymphatic obstruction.

作者信息

Lee J S

出版信息

Am J Physiol. 1986 Sep;251(3 Pt 1):G321-5. doi: 10.1152/ajpgi.1986.251.3.G321.

DOI:10.1152/ajpgi.1986.251.3.G321
PMID:3752247
Abstract

Lymph pressure (PL) in the main intestinal lymph duct with obstruction of lymph flow was determined. Under various conditions, the rate of lymph flow (JL) was essentially the same in either A rats (with communications between hepatic and intestinal lymphatics) or B rats (without such communications), but PL of A rats was significantly lower (P less than 0.01) than that of B rats. When the intestine was in the basal state, JL of A and B rats was 0.2-0.3 ml/h per rat, and PL was 1.5 +/- 0.2 and 3.3 +/- 0.2 mm/Hg, respectively. During fluid absorption, JL of A and B rats increased to 0.8-0.9 ml/h, and PL was 2.1 +/- 0.4 and 6.4 +/- 0.7 mmHg, respectively. During intravenous saline infusion, JL of A and B rats increased greatly to approximately 14 ml/h, and PL was 3.1 +/- 0.3 and 10.4 +/- 1.1 mmHg, respectively. The lower PL in A rats is apparently due to the possibility that during lymphatic obstruction most lymph could be drained off by the hepatic lymphatics. In A rats, luminal distension pressure had no effect on PL but in B rats PL decreased when distension pressure was 20 mmHg or higher. Furthermore, lymph pressure waves indicate the occurrence of rhythmical contractions of the lymph duct or its surrounding tissues, which may play a role in the propulsion of lymph.

摘要

测定了淋巴管阻塞时主肠淋巴管内的淋巴压力(PL)。在各种条件下,A组大鼠(肝淋巴管与肠淋巴管相通)和B组大鼠(肝淋巴管与肠淋巴管不相通)的淋巴流速(JL)基本相同,但A组大鼠的PL显著低于B组大鼠(P<0.01)。当肠道处于基础状态时,A组和B组大鼠的JL为0.2 - 0.3 ml/(h·只),PL分别为1.5±0.2和3.3±0.2 mmHg。在液体吸收过程中,A组和B组大鼠的JL增加到0.8 - 0.9 ml/(h·只),PL分别为2.1±0.4和6.4±0.7 mmHg。在静脉输注生理盐水期间,A组和B组大鼠的JL大幅增加至约14 ml/(h·只),PL分别为3.1±0.3和10.4±1.1 mmHg。A组大鼠较低的PL显然是由于在淋巴管阻塞期间,大部分淋巴可能通过肝淋巴管引流。在A组大鼠中,管腔内扩张压力对PL没有影响,但在B组大鼠中,当扩张压力为20 mmHg或更高时,PL降低。此外,淋巴压力波表明淋巴管或其周围组织发生有节律的收缩,这可能在淋巴推进中起作用。

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