Levo Y, Harbeck R J, Kirkpatrick C H
Int Arch Allergy Appl Immunol. 1985;77(4):413-5. doi: 10.1159/000233818.
The effect of different concentrations of hydrocortisone (HC) on the in vitro, pokeweed mitogen-driven synthesis of IgG and IgE by human lymphocytes was studied. HC had the same modulatory action on the production of both immunoglobulins. Two different effects were observed: the first is enhancement of Ig synthesis by low concentrations of HC (10(-7)-10(-4) M), and the second is inhibition of synthesis by higher concentrations due to lymphocytotoxic effect.
研究了不同浓度氢化可的松（HC）对人淋巴细胞在体外由商陆有丝分裂原驱动的IgG和IgE合成的影响。HC对两种免疫球蛋白的产生具有相同的调节作用。观察到两种不同的效应：第一种是低浓度HC（10^(-7)-10^(-4)M）增强Ig合成，第二种是高浓度时由于淋巴细胞毒性作用而抑制合成。
