Moradi Ghobad, Soheili Marzieh, Bahrami Pourya, Amini Elnaz Ezzati, Rashti Roya, Azadnia Arian, Zakaryaei Farima, Soheili Maryam, Moradi Yousef
Social Determinants of Health Research Center, Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran.
Department of Pharmaceutical and Administrative Sciences, College of Pharmacy Western New England University Springfield Massachusetts USA.
Health Sci Rep. 2025 Mar 2;8(3):e70500. doi: 10.1002/hsr2.70500. eCollection 2025 Mar.
The study's goal was to assess the global prevalence of HIV/AIDS infection in transgender people and to provide light on regional variances.
A systematic search was conducted across multiple databases, including PubMed (Medline), Scopus, Web of Science, Embase, Ovid, and PsycINFO, from inception until September 2023. Studies were selected based on predefined inclusion and exclusion criteria, and quality was assessed using the Newcastle-Ottawa Scale (NOS). Heterogeneity was evaluated using Cochran's and -squared statistics. A meta-analysis was performed using the random-effects model in Stata 17.0 (StataCorp, Texas, USA). A total of 3125 articles were identified, of which 37 studies met the inclusion criteria and were included in the systematic review and meta-analysis.
The global prevalence of HIV/AIDS among transgender populations was 24% (CI: 12%-39%). Regional analysis revealed higher rates of HIV/AIDS among male-to-female (MTF) transgender individuals in Asia (30%, CI: 5%-54%) and Africa (35%, CI: 13%-57%) compared to other regions. In contrast, female-to-male (FTM) transgender individuals in Asia had a higher prevalence (23%, CI: 9%-31%) than those in the Americas (11%, CI: 3%-23%).
Given the high prevalence of HIV/AIDS in the TG community worldwide and the significant variance within communities, it is critical to execute a comprehensive set of interventions to successfully prevent HIV/AIDS in transgender people.
本研究的目标是评估全球跨性别者中艾滋病毒/艾滋病感染的流行情况，并揭示地区差异。
对多个数据库进行了系统检索，包括PubMed（Medline）、Scopus、科学引文索引、Embase、Ovid和PsycINFO，检索时间从数据库建立至2023年9月。根据预先定义的纳入和排除标准选择研究，并使用纽卡斯尔-渥太华量表（NOS）评估质量。使用 Cochr an's Q和I²统计量评估异质性。使用Stata 17.0（美国德克萨斯州StataCorp公司）中的随机效应模型进行荟萃分析。共识别出3125篇文章，其中37项研究符合纳入标准，被纳入系统评价和荟萃分析。
全球跨性别者中艾滋病毒/艾滋病的流行率为24%（置信区间：12%-39%）。区域分析显示，与其他地区相比，亚洲（30%，置信区间：5%-54%）和非洲（35%，置信区间：13%-57%）的男变女（MTF）跨性别者中艾滋病毒/艾滋病感染率更高。相比之下，亚洲的女变男（FTM）跨性别者的流行率（23%，置信区间：9%-31%）高于美洲（11%，置信区间：3%-23%）。
鉴于全球跨性别群体中艾滋病毒/艾滋病的高流行率以及群体内部的显著差异，实施一套全面的干预措施对于成功预防跨性别者中的艾滋病毒/艾滋病至关重要。
