阿莫西林-克拉维酸与头孢氨苄治疗孕期菌尿症的对比研究。
Comparative study of amoxicillin-clavulanic acid and cephalexin in the treatment of bacteriuria during pregnancy.
作者信息
Pedler S J, Bint A J
出版信息
Antimicrob Agents Chemother. 1985 Apr;27(4):508-10. doi: 10.1128/AAC.27.4.508.
A comparative clinical trial of amoxicillin-clavulanic acid and cephalexin was carried out in 80 women with bacteriuria of pregnancy. Treatment was randomly allocated and consisted of either one tablet of amoxicillin plus clavulanic acid (250 and 125 mg, respectively) three times daily or cephalexin (250 mg) three times daily for 7 days. Overall bacteriological cure rates at 2 weeks were 77% in the amoxicillin-clavulanic acid group and 74% in the cephalexin group. At 6 weeks the respective rates were 76 and 60%. Twenty-five episodes of infection were with ampicillin-resistant strains; cure rates were 82% (2 weeks) and 80% (6 weeks) in the amoxicillin-clavulanic acid group and 85 and 64%, respectively, in the cephalexin group. Differences in cure rates were not statistically significant. No significant difference in the rate of side effects was found. In particular, no toxicity to the fetus was seen which could be ascribed to either drug. Amoxicillin-clavulanic acid would appear to be a safe and effective treatment for bacteriuria of pregnancy.
对80名妊娠合并菌尿症的女性进行了阿莫西林-克拉维酸与头孢氨苄的对比临床试验。治疗方案随机分配，一组为每日三次，每次服用一片阿莫西林加克拉维酸（分别为250毫克和125毫克），另一组为每日三次，每次服用头孢氨苄（250毫克），疗程均为7天。阿莫西林-克拉维酸组在2周时的总体细菌学治愈率为77%，头孢氨苄组为74%。6周时，相应治愈率分别为76%和60%。有25例感染由耐氨苄西林菌株引起；阿莫西林-克拉维酸组在2周和6周时的治愈率分别为82%和80%，头孢氨苄组则分别为85%和64%。治愈率差异无统计学意义。副作用发生率也无显著差异。特别是，未发现两种药物对胎儿有任何可归因的毒性。阿莫西林-克拉维酸似乎是治疗妊娠合并菌尿症的一种安全有效的药物。
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