Lovy M, MacCarter D, Steigerwald J C
Arthritis Rheum. 1985 May;28(5):496-501. doi: 10.1002/art.1780280505.
Nailfold capillary abnormalities in 42 consecutive patients with systemic sclerosis were studied by wide field capillary microscopy, and capillary abnormalities were correlated with organ involvement. Twenty-eight patients hd diffuse skin disease, and 14 had the CREST variant of systemic sclerosis (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasis) with anticentromere antibodies. Nailfold capillary enlargement and loss were graded from photographs. There was no correlation between the severity of either nailfold capillary loss or enlargement and duration of disease, number of organ systems involved, or acroosteolysis. The presence of telangiectasis correlated with extreme capillary enlargement (P less than 0.025). Based on these findings it can be concluded that nailfold capillary changes in individual patients with systemic sclerosis are not useful in predicting organ involvement.
对42例连续性系统性硬化症患者的甲襞毛细血管异常情况进行了宽视野毛细血管显微镜检查，并将毛细血管异常与器官受累情况进行了关联分析。28例患者患有弥漫性皮肤疾病，14例患有系统性硬化症的CREST变异型（钙质沉着、雷诺现象、食管运动障碍、指端硬化、毛细血管扩张）且伴有抗着丝点抗体。根据照片对甲襞毛细血管扩张和缺失情况进行分级。甲襞毛细血管缺失或扩张的严重程度与疾病持续时间、受累器官系统数量或骨质溶解均无相关性。毛细血管扩张的存在与极度毛细血管扩张相关（P小于0.025）。基于这些发现，可以得出结论，系统性硬化症个体患者的甲襞毛细血管变化对预测器官受累并无帮助。
