年龄和性别对乙酰水杨酸及其代谢产物处置的影响。
The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.
作者信息
Ho P C, Triggs E J, Bourne D W, Heazlewood V J
出版信息
Br J Clin Pharmacol. 1985 May;19(5):675-84. doi: 10.1111/j.1365-2125.1985.tb02695.x.
Abstract
The disposition of a low dose (600 mg) of acetylsalicylic acid (ASA) and its metabolites (salicylate, salicyluric acid and salicyl glucuronides) was studied in 25 male and female patients of different ages. Plasma levels of ASA and salicylate were found to be significantly higher in the females (young and elderly), whereas plasma levels of salicyluric acid were found to be significantly higher in the elderly (male and female) groups. The higher plasma levels of ASA and salicylate in the females appear to be due to an intrinsically lower metabolic activity in that sex, while the lower clearance of salicyluric acid leads to the accumulation of that compound in the aged. No age and sex effects were found to influence the volumes of distribution of ASA, salicylate and salicyluric acid.
摘要
在25名不同年龄的男性和女性患者中研究了低剂量（600毫克）乙酰水杨酸（ASA）及其代谢产物（水杨酸盐、水杨尿酸和水杨酸葡萄糖醛酸苷）的处置情况。发现女性（年轻和老年）体内ASA和水杨酸盐的血浆水平显著更高，而水杨尿酸的血浆水平在老年（男性和女性）组中显著更高。女性体内较高的ASA和水杨酸盐血浆水平似乎是由于该性别内在的代谢活性较低，而水杨尿酸较低的清除率导致该化合物在老年人中蓄积。未发现年龄和性别影响对ASA、水杨酸盐和水杨尿酸分布容积的影响。
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