Montgomery P R, Sitar D S
Gerontology. 1981;27(6):329-33. doi: 10.1159/000212493.
A high pressure liquid chromatographic method was used to measure the serum concentrations of salicylic, salicyluric and gentisic acids in patients receiving chronic acetylsalicylic acid therapy. There was good correlation between this method and the established colorimetric assay for salicylic acid. The concentration of gentisic and salicyluric acids were increased in patients older than 60 years. No correlation was found with sex, concomitant ingestion of other drugs, serum creatinine or serum albumin.
采用高压液相色谱法测定接受慢性乙酰水杨酸治疗患者血清中水杨酸、水杨尿酸和龙胆酸的浓度。该方法与已确立的水杨酸比色测定法具有良好的相关性。60岁以上患者龙胆酸和水杨尿酸的浓度升高。未发现与性别、同时服用其他药物、血清肌酐或血清白蛋白存在相关性。
