Lundqvist C, Simonsen T B, Siddiqui T G
Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway.
Faculty of Medicine, Inst. Clin. Med, Campus Ahus, University of Oslo, Norway.
Scand J Prim Health Care. 2025 Sep;43(3):555-562. doi: 10.1080/02813432.2025.2475300. Epub 2025 Mar 8.
Sleep disorders such as insomnia may occur in old age, potentially leading to z-hypnotic use. However, few studies have explored older adults' self-reported sleep concerns in relation to z-hypnotic use. We aim to examine this relationship.
We conducted a cross-sectional study using a web-based questionnaire to assess sleep disturbances and medication use (z-hypnotics, benzodiazepines, and opioid analgesics) among 5,194 older adults through 21 GPs in southeast Norway. The main outcome, inappropriate z-hypnotic use, was defined as self-reported use for ≥4 weeks at ≥ three times per week. We used descriptive statistics and exploratory logistic regression mixed-effects models for data analysis.
Among the 687 patients included in the study, 22% ( = 153) reported sleep disturbances. Of these, 84% ( = 575) did not use z-hypnotics, while 16% ( = 112) used z-hypnotics, 63% ( = 71) of these used them inappropriately. (≥4 weeks, ≥ three times per week). Patients with sleep disturbances (OR: 12.1, CI: 6.77 - 21.6, < 0.001), trouble falling or staying asleep (OR: 14.6, CI: 5.04-42.0, < 0.001), and multiple reasons for disturbances (pain, overthinking, or a family death) (OR: 3.58, CI: 1.85-6.93, < 0.001) had higher odds of inappropriate z-hypnotic use compared to those with no or occasional disturbances. Men had lower odds (OR: 0.54, CI: 0.30-0.97, = 0.039) than women. GP prescribing was not associated with inappropriate use, but men had lower odds (OR: 0.34, CI: 0.14-0.84, = 0.020) when prescribed by male GPs compared to women prescribed by female GPs.
A high proportion of patients used z-hypnotics inappropriately. This inappropriate use was associated with experienced sleep disturbances, particularly trouble falling asleep, trouble staying asleep, and multiple reasons for sleep disturbances. The prescribing GP was not significantly associated with inappropriate use.
失眠等睡眠障碍可能在老年时出现,这可能会导致使用Z类催眠药。然而,很少有研究探讨老年人自我报告的睡眠问题与Z类催眠药使用之间的关系。我们旨在研究这种关系。
我们进行了一项横断面研究,通过挪威东南部的21名全科医生,使用基于网络的问卷对5194名老年人的睡眠障碍和药物使用情况(Z类催眠药、苯二氮䓬类药物和阿片类镇痛药)进行评估。主要结果,即不适当使用Z类催眠药,被定义为自我报告每周使用≥3次且持续≥4周。我们使用描述性统计和探索性逻辑回归混合效应模型进行数据分析。
在纳入研究的687名患者中,22%(n = 153)报告有睡眠障碍。其中,84%(n = 575)未使用Z类催眠药,而16%(n = 112)使用了Z类催眠药,其中63%(n = 71)使用不当(≥4周,每周≥3次)。与没有或偶尔有睡眠障碍的患者相比,有睡眠障碍的患者(比值比:12.1,置信区间:6.77 - 21.6,P < 0.001)、入睡困难或睡眠维持困难的患者(比值比:14.6,置信区间:5.04 - 42.0,P < 0.001)以及有多种干扰因素(疼痛、过度思考或家人死亡)的患者(比值比:3.58,置信区间:1.85 - 6.93,P < 0.001)不适当使用Z类催眠药的几率更高。男性的几率低于女性(比值比:0.54,置信区间:0.30 - 0.97,P = 0.039)。全科医生的处方与不适当使用无关,但与女性全科医生开处方的女性患者相比,男性全科医生开处方的男性患者几率更低(比值比:0.34,置信区间:0.14 - 0.84,P = 0.020)。
很大一部分患者不适当使用Z类催眠药。这种不适当使用与经历的睡眠障碍有关,特别是入睡困难、睡眠维持困难以及多种睡眠障碍原因。开处方的全科医生与不适当使用没有显著关联。