R Srinath Bhradwaj, Sarin Aditya, Aggarwal Shyam, Halder Shikha, Hukku S, Mustafa Taha, Arora Vijay, Malik V K, Singh Shivendra, Rao G V, Saklani Avinash, Bhojwani Rajesh, Rawat Saumitra, Selvasekar C, Parikh Purvish M
Department of Medical Oncology, Apollo Cancer Institutes, Hyderabad, Telangana, India.
Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India.
South Asian J Cancer. 2025 Jan 28;13(4):274-280. doi: 10.1055/s-0045-1802334. eCollection 2024 Oct.
A major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as reducing systemic relapses, thus increasing overall survival. Details of the four key TNT trials are discussed. They pave the way for nonoperative management for patients who achieve clinical complete responses.
直肠癌治疗的一项重大进展是有证据支持短程放疗和长程放化疗。两者均已显示可改善局部治疗效果。全新辅助治疗（TNT）是新出现的方法，它在改善局部反应以及减少全身复发方面提供了进一步的益处，从而提高了总体生存率。文中讨论了四项关键TNT试验的细节。它们为达到临床完全缓解的患者的非手术治疗铺平了道路。
