Stallings R L, Munk A C, Longmire J L, Jett J H, Wilder M E, Siciliano M J, Adair G M, Crawford B D
Chromosoma. 1985;92(2):156-63. doi: 10.1007/BF00328468.
Proto-oncogenes, which represent the cellular progenitors of the transforming genes harbored by acute transforming oncogenic retroviruses, have been highly conserved during vertebrate evolution. In this report, we have assigned experimentally a subset of proto-oncogenes (SRC, ABL, FES, and FMS-all related to the SRC family) to Chinese hamster chromosomes by Southern filter hybridization analyses of DNAs isolated from both somatic cell hybrids and flow-sorted hamster chromosomes. These results demonstrate that several autosomal linkage groups containing proto-oncogenes originated prior to the radiation and speciation of mammals and have remained remarkably stable for nearly 80 million years.
原癌基因是急性转化致癌逆转录病毒所携带的转化基因的细胞祖先，在脊椎动物进化过程中高度保守。在本报告中，我们通过对从体细胞杂种和流式分选的仓鼠染色体中分离的DNA进行Southern杂交分析，将一组原癌基因（SRC、ABL、FES和FMS，均与SRC家族相关）实验定位到中国仓鼠染色体上。这些结果表明，几个包含原癌基因的常染色体连锁群在哺乳动物辐射和物种形成之前就已形成，并且在近8000万年里一直保持着显著的稳定性。
