Sakaguchi A Y, Zabel B U, Grzeschik K H, Law M L, Ellis R W, Scolnick E M, Naylor S L
Mol Cell Biol. 1984 May;4(5):989-93. doi: 10.1128/mcb.4.5.989-993.1984.
Human cellular Kirsten ras1 and ras2 genes were localized to chromosomes 6p23 ----q12 and 12p12 .05----pter, respectively, using human-rodent cell hybrids. Thus, the short arms of human chromosomes 11 (encoding lactate dehydrogenase-A and the proto-oncogene c-Ha- ras1 ) and 12 (encoding lactate dehydrogenase B and c-Ki- ras2 ) share at least two pairs of genes that probably evolved from common ancestral genes.
利用人-啮齿动物细胞杂种,将人类细胞的 Kirsten ras1 和 ras2 基因分别定位到染色体 6p23 ----q12 和 12p12.05----pter 上。因此,人类染色体 11(编码乳酸脱氢酶-A 和原癌基因 c-Ha- ras1)和 12(编码乳酸脱氢酶 B 和 c-Ki- ras2)的短臂至少共享两对可能从共同祖先基因进化而来的基因。