Montemurro Nicola, Ius Tamara, Ortenzi Valerio, Pasqualetti Francesco, Acerbi Francesco
Department of Neurosurgery, Azienda Ospedaliero Universitaria Pisana (AOUP), Pisa, Italy.
Head-Neck and Neurosciences Department, Santa Maria Della Misericordia University Hospital, Udine, Italy.
Neurol Sci. 2025 Mar 11. doi: 10.1007/s10072-025-08084-z.
Intramedullary spinal cord metastasis (ISCM) is rare and affects 0.9-2.1% of all cancer patients. Colorectal cancer accounts for about 3% of all ISCMs.
A systematic review of the literature in the most common electronic database (PubMed, Ovid MEDLINE and Ovid EMBASE) on cervical ISCM from colon cancer, according with "PRISMA statement" criteria, was done. In addition, we present a 76-year-old man with progressive paraparesis and negative anamnesis for primary tumors, who underwent surgical and complete resection of a C5-C6 intramedullary spinal cord colon metastasis.
From a systematic review of the literature, only 8 previous cases of cervical ISCM from colon cancer were reported. The mean age at presentation was 68.3 years. Surgery was performed in 6 patients, including our case, whereas 1 patient was treated with radiotherapy and two patients were untreated. Survival time ranges from 2 weeks to 14 months (mean 3.8 months). The survival rates at 60 days and 120 days are 50% and 12.5%, respectively.
Cervical ISCM from colon cancer is rare and is usually detected at an advanced stage of primary tumor disease. The prognosis is poor and definitive recommendations cannot be made due to the lack of controlled comparative clinical studies.
脊髓髓内转移（ISCM）较为罕见，在所有癌症患者中占0.9 - 2.1%。结直肠癌约占所有脊髓髓内转移病例的3%。
按照“PRISMA声明”标准，对最常用电子数据库（PubMed、Ovid MEDLINE和Ovid EMBASE）中关于结肠癌所致颈段脊髓髓内转移的文献进行系统综述。此外，我们报告一名76岁男性，出现进行性双下肢轻瘫且既往无原发性肿瘤病史，其接受了C5 - C6节段脊髓髓内结肠癌转移灶的手术全切。
通过文献系统综述，此前仅报道过8例结肠癌所致颈段脊髓髓内转移病例。发病时的平均年龄为68.3岁。6例患者（包括我们的病例）接受了手术，1例患者接受了放疗，2例患者未接受治疗。生存时间为2周 - 14个月（平均3.8个月）。60天和120天的生存率分别为50%和12.5%。
结肠癌所致颈段脊髓髓内转移罕见，通常在原发性肿瘤疾病晚期被发现。预后较差，由于缺乏对照比较临床研究，无法给出确切建议。
