Riedmann Kyle, Gay Sean, Lott Sarah Averill, Berent Jonathan, Buhl Derek L, Dzierzewski Joseph M, Kabiri Nina Shaafi, Kramer Frank, Kremliovsky Michael, Seitz Christian, Testelmans Dries, Thomas Kevin, de Vries Herman, Fromy Piper
Digital Medicine Society, Boston, MA, USA.
Vanderbilt University, Nashville, TN, USA.
Qual Life Res. 2025 Mar 11. doi: 10.1007/s11136-025-03932-z.
Sleep, a vital pillar of health, impacts daily functioning and overall quality of life. Despite extensive research on sleep disturbances within specific therapeutic areas (TAs), there's limited understanding of how these disturbances affect patients across multiple TAs. This systematic literature review adopts a patient-centered approach to explore the meaningful aspects of health and concepts of interest relating to sleep and sleep disturbances across a variety of TAs, utilizing qualitative research to bridge the gap between patient experiences and clinical measures.
A systematic search was conducted in Embase and PubMed for qualitative studies on sleep within selected TAs, using a pre-registered strategy. Initial screenings based on titles and abstracts were followed by full-text reviews and quality appraisal using the CASP checklist.
From 4331 unique publications, 52 full-text articles were analyzed across 11 TAs. Thematic analysis highlighted issues within the sleep window, and proximal and distal impacts of sleep disturbances. Using thematic analysis a conceptual model was developed, illustrating a multitude of sleep disturbances from a patient-first perspective, which emphasized sleep quality's role in daily functionality.
This review emphasizes the importance of incorporating patient perspectives into sleep research and clinical practice. By presenting a holistic conceptual model, it provides a foundation for developing outcome measures that reflect meaningful aspects of patients' sleep experiences. This patient-centered approach highlights the need for novel methodologies in sleep research, beyond traditional clinical outcome assessments, to capture the full spectrum of sleep disturbances' impacts on patients' lives across various TAs.
睡眠是健康的重要支柱，影响日常功能和整体生活质量。尽管在特定治疗领域（TA）对睡眠障碍进行了广泛研究，但对于这些障碍如何影响多个TA中的患者，人们了解有限。本系统文献综述采用以患者为中心的方法，探讨与各种TA中睡眠和睡眠障碍相关的健康有意义方面及感兴趣的概念，利用定性研究弥合患者体验与临床测量之间的差距。
使用预先注册的策略，在Embase和PubMed中对选定TA内关于睡眠的定性研究进行系统检索。基于标题和摘要进行初步筛选，随后使用CASP清单进行全文审查和质量评估。
从4331篇独特出版物中，对11个TA的52篇全文文章进行了分析。主题分析突出了睡眠时段内的问题以及睡眠障碍的近端和远端影响。通过主题分析，开发了一个概念模型，从患者优先的角度说明了多种睡眠障碍，强调了睡眠质量在日常功能中的作用。
本综述强调将患者观点纳入睡眠研究和临床实践的重要性。通过提出一个整体概念模型，它为开发反映患者睡眠体验有意义方面的结局测量提供了基础。这种以患者为中心的方法突出了睡眠研究中除传统临床结局评估之外采用新方法的必要性，以全面了解睡眠障碍对不同TA中患者生活的影响。
