在无幽门螺杆菌的患者胃活检中证实存在具核梭杆菌。

Fusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.

作者信息

Kamali Negin, Talebi Bezmin Abadi Amin, Rahimi Farid, Forootan Mojgan

机构信息

Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Room 107, First floor, Tehran, Iran.

Research School of Biology, The Australian National University, Ngunnawal and Ngambri Country, Canberra, ACT, Australia.

出版信息

BMC Res Notes. 2025 Mar 11;18(1):109. doi: 10.1186/s13104-025-07165-8.

DOI:10.1186/s13104-025-07165-8

PMID:40069707

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11899000/

Abstract

OBJECTIVE

Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.

RESULTS

Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included. One hundred and eighty (60%) patients were negative and 120 (40%) positive for H. pylori. Associations between the presence of H. pylori and age, gender, or other demographics were statistically insignificant (p > 0.05). The prevalence of F. nucleatum infection was determined for the two patient categories: 215 patients (72%) were positive for F. nucleatum; of these cases, 95 showed evidence of, and 120 lacked, concomitant H. pylori infection. Gastric biopsies obtained from patients with gastric cancer but negative for H. pylori revealed a significant prevalence of F. nucleatum infection.

摘要

目的

先前已有关于某些细菌与胃癌之间可能存在关联的描述；然而，此类关联背后的机制尚未完全明晰。我们旨在确认在患有胃十二指肠疾病（包括胃癌）的患者活检样本中是否存在具核梭杆菌，这些患者伴有或不伴有幽门螺杆菌感染。

结果

纳入了300例患有胃十二指肠疾病的患者，包括胃炎、十二指肠溃疡或胃癌。180例（60%）患者幽门螺杆菌检测为阴性，120例（40%）为阳性。幽门螺杆菌的存在与年龄、性别或其他人口统计学特征之间的关联在统计学上无显著意义（p＞0.05）。对两类患者确定了具核梭杆菌感染的患病率：215例患者（72%）具核梭杆菌检测为阳性；在这些病例中，95例有同时感染幽门螺杆菌的证据，120例没有。从胃癌患者但幽门螺杆菌检测为阴性的患者获取的胃活检样本显示具核梭杆菌感染的患病率很高。