Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas 44307, Lithuania.
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg 39120, Germany.
World J Gastroenterol. 2024 Sep 21;30(35):3972-3984. doi: 10.3748/wjg.v30.i35.3972.
() is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation, such as periodontitis and gingivitis. In the last 10 years, has been identified as a prevalent bacterium associated with colorectal adenocarcinoma and has also been linked to cancer progression, metastasis and poor disease outcome. While the role of in colon carcinogenesis has been intensively studied, its role in gastric carcinogenesis is still poorly understood. Although infection has historically been recognized as the strongest risk factor for the development of gastric cancer (GC), with recent advances in DNA sequencing technology, other members of the gastric microbial community, and in particular, have received increasing attention. In this review, we summarize the existing knowledge on the involvement of in gastric carcinogenesis and address the potential translational and clinical significance of in GC.
() 是一种革兰氏阴性厌氧菌，在口腔炎症（如牙周炎和牙龈炎）的发展中起关键作用。在过去的 10 年中， 已被确定为与结直肠腺癌相关的常见细菌，并且与癌症进展、转移和不良疾病结局有关。虽然 在结肠癌变中的作用已得到深入研究，但它在胃癌发生中的作用仍知之甚少。尽管 感染历来被认为是胃癌（GC）发展的最强危险因素，但随着 DNA 测序技术的最新进展，胃微生物群落的其他成员，特别是 ，受到了越来越多的关注。在这篇综述中，我们总结了 在胃癌发生中的作用的现有知识，并探讨了 在 GC 中的潜在转化和临床意义。
