Alogaili Methaq H, Alsallami Afnan A
Deptartment of Family and Community Medicine, College of Medicine, Al-Nahrain University, Baghdad, Iraq.
College of Medicine, Al-Nahrain University, Baghdad, Iraq.
Int J Endocrinol Metab. 2024 Aug 3;22(2):e145894. doi: 10.5812/ijem-145894. eCollection 2024 Apr.
Insulin resistance is a critical first step in the development of many chronic diseases such as diabetes, hypertension, and coronary artery disease (CAD). Early recognition of changes in insulin sensitivity and subsequent glycolipid dysregulation is paramount in reversing the progression of these diseases. Since the prevalence of insulin resistance is relatively high, there is a demand for a simple, easy, and inexpensive method for its detection.
To assess the association of metabolic score for insulin resistance (METS-IR) with prehypertension (preHTN) in normoglycemic individuals.
A cross-sectional study included two groups with normal blood glucose levels (age and sex matched, 179 adults each) with and without preHTN. Those with a history of hypertension, diabetes, CAD, or on chronic drug treatment were excluded from the study. Metabolic score for insulin resistance was calculated as Ln [(2 × FPG (mg/dL) + fasting TG (mg/dL)] × BMI (kg/m²)/Ln [HDL-c (mg/dL)].
The METS-IR score was significantly higher in those with preHTN (P < 0.001). One-way ANOVA showed significant differences in BMI, TG, and HDL-c according to METS-IR quartiles. Cox regression analysis showed that METS-IR is a single independent predictor of preHTN (OR = 1.3, 95% CI 1.20, 1.34).
Metabolic score for insulin resistance is significantly associated with and an independent predictor of prehypertension in euglycemic people.
胰岛素抵抗是许多慢性疾病（如糖尿病、高血压和冠状动脉疾病（CAD））发展过程中的关键第一步。早期识别胰岛素敏感性变化以及随后的糖脂代谢失调对于逆转这些疾病的进展至关重要。由于胰岛素抵抗的患病率相对较高，因此需要一种简单、易行且廉价的检测方法。
评估正常血糖个体中胰岛素抵抗代谢评分（METS-IR）与高血压前期（preHTN）的关联。
一项横断面研究纳入了两组血糖水平正常的人群（年龄和性别匹配，每组179名成年人），一组有高血压前期，另一组没有。有高血压、糖尿病、CAD病史或正在接受慢性药物治疗的患者被排除在研究之外。胰岛素抵抗代谢评分的计算方法为：Ln[(2×空腹血糖（mg/dL）+空腹甘油三酯（mg/dL）]×体重指数（kg/m²）/Ln[高密度脂蛋白胆固醇（mg/dL）]。
高血压前期患者的METS-IR评分显著更高（P<0.001）。单因素方差分析显示，根据METS-IR四分位数，体重指数、甘油三酯和高密度脂蛋白胆固醇存在显著差异。Cox回归分析表明，METS-IR是高血压前期的单一独立预测因素（OR=1.3，95%CI 1.20，1.34）。
胰岛素抵抗代谢评分与血糖正常人群的高血压前期显著相关，且是其独立预测因素。
