Pipitone Giuseppe, Abbott Michelle, Gizzi Andrea, Buscemi Calogero, Guida Marascia Federica, Imburgia Claudia, Ciusa Giacomo, La Sala Alba, Mancuso Giuseppe Giorgio, Messana Domenico, Cascio Antonio, Iaria Chiara
Infectious Disease Unit, ARNAS Civico-Di Cristina, Palermo, Italy.
Bronchial Endoscopy Unit, ARNAS Civico-Di Cristina, Palermo, Italy.
Infez Med. 2025 Mar 1;33(1):130-138. doi: 10.53854/liim-3301-13. eCollection 2025.
Syphilitic pneumonia is a rare secondary form of infection. In this article, we present a case of syphilitic pneumonia in a patient living with Human Immunodeficiency Virus (HIV) with good immune-virological status. We also performed a systematic review of literature and we found 43 cases of syphilitic pneumonia described since 1886. We added our case report and performed a statistical analysis. Our analysis showed that 40/44 (91%) were males, with a median age of 46 years old (IQR 37-56), 9/28 (32%) were people living with HIV (data not available for 16/44 patients), 17/27 (63%) had syphilitic-related hepatitis during the clinical presentation (data not available for 17/44 patients), and 28/42 (66.6%) of patients had maculopapular rash compatible with secondary forms (data not available for 2/42 patients). Furthermore, 74.4% of patients had nodular lesions on chest X-ray or pulmonary Computed Tomography scan. Given the high rate of nodular pneumonia among patients, clinicians should consider it as a common presentation in syphilitic pneumonia.
梅毒性肺炎是一种罕见的继发性感染形式。在本文中，我们报告了一例患有梅毒肺炎的人类免疫缺陷病毒（HIV）感染者，其免疫病毒学状态良好。我们还对文献进行了系统回顾，发现自1886年以来共描述了43例梅毒性肺炎病例。我们补充了我们的病例报告并进行了统计分析。我们的分析表明，44例中有40例（91%）为男性，中位年龄为46岁（四分位间距37 - 56岁），28例中有9例（32%）为HIV感染者（44例中有16例数据不可用），临床表现时27例中有17例（63%）患有梅毒相关性肝炎（44例中有17例数据不可用），42例中有28例（66.6%）患者出现符合二期梅毒的斑丘疹（42例中有2例数据不可用）。此外，74.4%的患者在胸部X线或肺部计算机断层扫描中有结节性病变。鉴于患者中结节性肺炎的发生率较高，临床医生应将其视为梅毒性肺炎的常见表现。
