Bernardi M, Servadei D, Trevisani F, Rusticali A G, Gasbarrini G
Digestion. 1985;31(4):189-93. doi: 10.1159/000199198.
23 cirrhotics with ascites and sodium retention, whose aldosteronemia had been evaluated after an equilibration period at controlled sodium intake at the occasion of previous studies, were retrospectively investigated. The dosage of spironolactone needed to induce a negative sodium balance correlated significantly with plasma aldosterone concentration: r = 0.64; p less than 0.001. However, in cases with plasma albumin concentration less than 3 g/dl, glomerular filtration rate less than 80 ml/min, and plasma sodium concentration less than 136 mmol/l such a relationship was no longer significant. The diuretic response to spironolactone is mainly linked to plasma aldosterone concentration. Factors affecting the removal of ascites from the peritoneal cavity and renal sodium handling can influence the expected diuretic response to the drug.
对23例伴有腹水和钠潴留的肝硬化患者进行了回顾性研究，这些患者在之前的研究中，在钠摄入受控的平衡期后评估了醛固酮血症。诱导负钠平衡所需的螺内酯剂量与血浆醛固酮浓度显著相关：r = 0.64；p < 0.001。然而，在血浆白蛋白浓度低于3 g/dl、肾小球滤过率低于80 ml/min和血浆钠浓度低于136 mmol/l的情况下，这种关系不再显著。对螺内酯的利尿反应主要与血浆醛固酮浓度有关。影响腹水从腹腔清除和肾脏钠处理的因素会影响对该药物预期的利尿反应。
