Pieterse A S, Leong A S, Rowland R
Hum Pathol. 1985 Jul;16(7):683-8. doi: 10.1016/s0046-8177(85)80152-0.
The clinical and pathologic findings in 11 patients with pneumatosis cystoides intestinalis (PCI) are described. Symptoms were variable but localized to the gastrointestinal tract. Only one patient had obstructive airway disease. Although gas cysts of varying sizes were present in the colonic wall in all cases, distinctive changes were also observed in the mucosa. Architectural disturbances were seen in 11 of 13 specimens, and changes mimicking those of inflammatory bowel disease, including cryptitis, crypt abscesses, chronic inflammation, and granulomas, were present. In addition, crypt dilation and partial crypt rupture, with formation of intramucosal cysts, were seen in association with clusters of small gas cysts in the lamina propria. The transgression of gas cysts through the muscularis mucosae and the presence of larger giant cell-lined cysts in the submucosa suggested entry of gas generated in the colonic lumen or within inflamed crypts from the mucosal aspect. Other postulated pathogeneses of PCI are discussed.
本文描述了11例肠气囊肿症（PCI）患者的临床和病理表现。症状多样，但局限于胃肠道。只有1例患者患有阻塞性气道疾病。虽然所有病例的结肠壁均存在大小不一的气囊肿，但黏膜也观察到了明显变化。13个标本中有11个出现结构紊乱，且存在类似炎症性肠病的改变，包括隐窝炎、隐窝脓肿、慢性炎症和肉芽肿。此外，在固有层小群气囊肿附近可见隐窝扩张和部分隐窝破裂，并形成黏膜内囊肿。气囊肿穿过黏膜肌层以及黏膜下层存在由较大巨细胞衬里的囊肿，提示结肠腔内或炎症隐窝内产生的气体从黏膜面进入。文中还讨论了PCI的其他假定发病机制。
