Karsch Julia, Schönfeld Mascha, Mühler Ann-Kathrin, Tippmann Susanne, Arnold Christine, Urschitz Michael S, Mildenberger Eva, Kidszun André
Division of Neonatology, Center for Pediatric and Adolescent Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.
Division of Neonatology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Health Qual Life Outcomes. 2025 Mar 15;23(1):24. doi: 10.1186/s12955-025-02345-3.
Health-related quality of life is an important measure of patient-reported outcomes. There is limited evidence on how parental health-related quality of life develops after neonatal hospitalization.
To evaluate parents' health-related quality of life (HRQL) during the year following their infant's treatment in the neonatal intensive care unit (NICU).
This prospective cohort study, conducted at a German university hospital between 2020 - 2023, examined HRQL among parents of infants hospitalized in the NICU for ≥ 14 days and parents of infants discharged from the maternity ward according to PedsQL™ Family Impact Module. Multiple linear regression analysis was performed to identify associations between cohort affiliation and differences in parental HRQL. Key secondary outcome was parenting sense of competence (PSOC).
Participants included 131 parents of NICU infants and 122 unexposed parents. HRQL increased over time for NICU mothers (58.7 at 14 days, 70.8 at 6 months, 77.0 at 12 months after birth) and NICU fathers (69.8 at 14 days, 73.9 at 6 months, 75.7 at 12 months). NICU treatment was significantly associated with lower HRQL at 14 days (mothers: -20.26 points; P < .001; fathers: -9.40 points; P = .04), but not at 6 or 12 months after birth. At 12 months postpartum, NICU mothers showed higher PSOC compared to unexposed mothers (mean difference -4.85; P = 0.005).
Parents and especially mothers of NICU infants reported lower HRQL at 14 days postpartum. At 6 and 12 months, their HRQL improved, aligning with that of unexposed parents.
健康相关生活质量是患者报告结局的一项重要衡量指标。关于新生儿住院后父母的健康相关生活质量如何发展，证据有限。
评估婴儿在新生儿重症监护病房（NICU）接受治疗后一年内父母的健康相关生活质量（HRQL）。
这项前瞻性队列研究于2020年至2023年在一家德国大学医院进行，根据儿童生活质量量表（PedsQL™）家庭影响模块，对在NICU住院≥14天的婴儿的父母以及从产科病房出院的婴儿的父母的HRQL进行了检查。进行了多元线性回归分析，以确定队列归属与父母HRQL差异之间的关联。关键次要结局是育儿胜任感（PSOC）。
参与者包括131名NICU婴儿的父母和122名未暴露组的父母。NICU母亲（出生后14天为58.7，6个月时为70.8，12个月时为77.0）和NICU父亲（出生后14天为69.8，6个月时为73.9，12个月时为75.7）的HRQL随时间增加。NICU治疗在出生后14天与较低的HRQL显著相关（母亲：-20.26分；P<0.001；父亲：-9.40分；P=0.04），但在出生后6个月或12个月时并非如此。产后12个月时，与未暴露组母亲相比，NICU母亲的PSOC更高（平均差异-4.85；P=0.005）。
NICU婴儿的父母，尤其是母亲，在产后14天报告的HRQL较低。在6个月和12个月时，他们的HRQL有所改善，与未暴露组父母的HRQL一致。
