Diesse Joël Martial, Jadhav Sushama, Tamekou Stephen Lacmata, Simo Gustave, Dzoyem Jean Paul, Souopgui Jacob, Kuiate Jules-Roger, Nema Vijay
Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Division of Molecular Biology, Indian Council of Medical Research - National Institute of Translational Virology and AIDS Research , 73 G MIDC Bhosari, Pune, 411026, India.
Diabetol Metab Syndr. 2025 Mar 15;17(1):86. doi: 10.1186/s13098-025-01653-4.
This study investigates the gut microbiota components associated with metabolic syndrome in patients living with HIV-1 at Bafoussam Regional Hospital, West Cameroon, it focuses on gastrointestinal mucosal barrier disruption and dysbiosis, and their effects on persistent inflammation and metabolic disorders.
A pilot study was conducted involving fourteen patients living with HIV-1. The patients were divided into two groups of seven in each group. One group consisted of patients with metabolic syndrome, and the other group included patients without metabolic syndrome. Gut microbiota was characterized using 16 S rRNA gene-targeted sequencing to analyze microbial diversity and composition. Beta diversity and the relative abundance of bacterial taxa were compared between patients with and without metabolic syndrome.
Patients living with HIV-1 and metabolic syndrome showed significantly altered beta diversity compared to those without metabolic syndrome. A higher relative abundance of Firmicutes and increased proliferation of Proteobacteria were observed in patients with metabolic syndrome. Additionally, a decrease in metabolically beneficial bacteria, such as Bifidobacterium sp., Lactobacillus sp., Akkermansia sp., and Faecalibacterium sp., was noted. Several beneficial bacterial species were associated with participants' metadata, suggesting potential links between gut microbiota and metabolic syndrome.
This preliminary study highlights that gut microbial balance, rather than the presence of specific bacteria, plays a crucial role in managing metabolic health in patients living with HIV-1. The altered gut microbiota in participants with metabolic syndrome emphasizes the need for further research into the optimal gut microbial structure. Understanding the interaction between gut microbiota changes and the chemical environment in these patients could guide targeted interventions to improve metabolic outcomes.
本研究调查了喀麦隆西部巴富萨姆地区医院感染人类免疫缺陷病毒1型（HIV-1）患者中与代谢综合征相关的肠道微生物群组成，重点关注胃肠道黏膜屏障破坏和生态失调及其对持续性炎症和代谢紊乱的影响。
进行了一项试点研究，纳入了14名HIV-1感染者。患者被分为两组，每组7人。一组为患有代谢综合征的患者，另一组为无代谢综合征的患者。使用靶向16S rRNA基因的测序对肠道微生物群进行表征，以分析微生物多样性和组成。比较了有和无代谢综合征患者之间的β多样性和细菌分类群的相对丰度。
与无代谢综合征的患者相比，感染HIV-1且患有代谢综合征的患者β多样性显著改变。在患有代谢综合征的患者中观察到厚壁菌门的相对丰度较高，变形菌门的增殖增加。此外，还注意到代谢有益菌如双歧杆菌属、乳杆菌属、阿克曼氏菌属和粪杆菌属的减少。几种有益细菌物种与参与者的元数据相关，表明肠道微生物群与代谢综合征之间存在潜在联系。
这项初步研究强调，肠道微生物平衡而非特定细菌的存在，在管理HIV-1感染者的代谢健康方面起着关键作用。代谢综合征参与者肠道微生物群的改变强调了进一步研究最佳肠道微生物结构的必要性。了解这些患者肠道微生物群变化与化学环境之间的相互作用，可为改善代谢结果的靶向干预提供指导。
