Olsen J, Sabreo S, Fasting U
J Epidemiol Community Health. 1985 Jun;39(2):165-8. doi: 10.1136/jech.39.2.165.
The aim of this study is to present risk assessments for the combined effect of alcohol and tobacco in cancer of the larynx. The case control study included all newly diagnosed laryngeal cancer patients under the age of 75 in Denmark during the years 1980-2. Four age and sex matched controls were selected using the municipal person registry in which the case was listed. Ninety six per cent of all cases and 78% of controls participated in the study, which is based on 326 cases and 1134 controls. Information on alcohol consumption and tobacco use was obtained by means of mailed questionnaires. For all laryngeal cancers as well as for the subgroups concerning cancer of the glottis and supraglottis alcohol consumption and tobacco use were found to be important risk factors. The effect of joint exposure was greater than the effect predicted from the sum of effects of each factor acting separately. Thus the combined effect follows a multiplicative rather than additive model.
本研究旨在呈现酒精和烟草共同作用对喉癌的风险评估。病例对照研究纳入了1980年至1982年间丹麦所有新诊断出的75岁以下喉癌患者。使用列出病例的市政人口登记册选取了4名年龄和性别匹配的对照。所有病例中的96%和对照中的78%参与了该研究，该研究基于326例病例和1134名对照。通过邮寄问卷获取饮酒和吸烟信息。对于所有喉癌以及声门癌和声门上癌亚组，饮酒和吸烟均被发现是重要的风险因素。联合暴露的影响大于各因素单独作用的影响之和所预测的效果。因此，联合效应遵循乘法模型而非加法模型。
